Takano K, Hizuka N, Tanaka I, Shizume K
Endocrinol Jpn. 1985 Aug;32(4):511-6. doi: 10.1507/endocrj1954.32.511.
A 12-year old girl was admitted to our hospital for evaluation of her short stature. Her height was below -3.5 SD of the mean height for her age. She was diagnosed as having craniopharyngioma and treated surgically. Thereafter she was treated with thyroxine and hydrocortisone. One and a half years later, she revisited our hospital for treatment of short stature. Her plasma GH did not respond to insulin-induced hypoglycemia but increased after hGRF-44 administration, indicating hGRF deficiency. hGRF was therefore administered at a dosage of 100 micrograms twice a day subcutaneously for three months. Her height increased 1.6 cm during treatment, which corresponded to a height increase of 6.4 cm/year. These findings indicate that hGRF treatment stimulates height increase in patients with GRF deficiency. For complete evaluation of hGRF therapy, further studies will be required.
一名12岁女孩因身材矮小被收治入院。她的身高低于其年龄平均身高的-3.5标准差。她被诊断患有颅咽管瘤并接受了手术治疗。此后，她接受了甲状腺素和氢化可的松治疗。一年半后，她因身材矮小再次来我院治疗。她的血浆生长激素对胰岛素诱导的低血糖无反应，但在给予hGRF-44后升高，提示hGRF缺乏。因此，给予hGRF皮下注射，剂量为100微克，每日两次，共三个月。治疗期间她的身高增加了1.6厘米，相当于每年身高增加6.4厘米。这些结果表明，hGRF治疗可刺激GRF缺乏患者的身高增长。为了全面评估hGRF治疗效果，还需要进一步的研究。
