Li Peng, Zhao Jiangna, Wei Xiuxiang, Luo Longfei, Chu Yuzhou, Zhang Tao, Zhu Anning, Yan Juntao
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, China.
Department of clinical medicine, Xiamen medical college, xiamen, China.
Chin Med. 2024 Oct 4;19(1):135. doi: 10.1186/s13020-024-00990-2.
Depression has emerged as a significant global health concern, exerting a profound impact on individuals, as evidenced by its high prevalence and associated suicide rates. Considering its pervasive nature, the absence of optimal treatment modalities remains a challenge. Acupuncture has garnered substantial clinical and experimental validation for its efficacy in addressing diverse forms of depression, including postpartum, post-stroke, and adolescent depression. This article endeavors to elucidate the distinctive attributes and underlying mechanisms of acupuncture in the contemporary treatment of depression. Research has demonstrated that acupuncture exerts diverse physiological effects in animal models of depression, encompassing modulation of the brain, serum, and brain-gut axis. These effects are attributed to various mechanisms, including anti-inflammatory and anti-oxidative actions, promotion of neuronal plasticity, neuroprotection, neurotrophic effects, modulation of neurotransmitters, regulation of endocrine and immune functions, and modulation of cell signal pathways. Currently, the therapeutic mechanism of acupuncture involves the engagement of multiple targets, pathways, and bidirectional regulation. Hence, acupuncture emerges as a promising alternative medical modality, exhibiting substantial research prospects and meriting comprehensive worth further study and dissemination.
抑郁症已成为全球重大的健康问题，其高患病率和相关自杀率表明它对个人产生了深远影响。鉴于其普遍性，缺乏最佳治疗方式仍是一项挑战。针灸在治疗包括产后、中风后和青少年抑郁症在内的多种形式抑郁症方面的疗效已获得大量临床和实验验证。本文旨在阐明针灸在当代抑郁症治疗中的独特属性和潜在机制。研究表明，针灸在抑郁症动物模型中发挥多种生理作用，包括对大脑、血清和脑-肠轴的调节。这些作用归因于多种机制，包括抗炎和抗氧化作用、促进神经元可塑性、神经保护、神经营养作用、调节神经递质、调节内分泌和免疫功能以及调节细胞信号通路。目前，针灸的治疗机制涉及多个靶点、途径和双向调节。因此，针灸成为一种有前景的替代医学模式，具有巨大的研究前景，值得全面深入研究和推广。
