基于“微生物群-肠-脑轴”理论的调神针法治疗脑卒中后抑郁的临床疗效：一项随机对照研究
Clinical Efficacy of Mind-Regulating Acupuncture on Post-Stroke Depression Based on the "Microbiota-Gut-Brain Axis" Theory: A Randomized Controlled Study.
作者信息
Xie Jingjun, Li Jinxia, Sun Qi, Jiang Jie
机构信息
Department of Acupuncture, The First People's Hospital of Huzhou, Huzhou, Zhejiang Province, People's Republic of China.
Department of Acupuncture, Huzhou Hospital of Traditional Chinese Medicine, Affiliated to Zhejiang Chinese Medical University, Huzhou, Zhejiang Province, People's Republic of China.
出版信息
Neuropsychiatr Dis Treat. 2025 Jul 7;21:1349-1358. doi: 10.2147/NDT.S525238. eCollection 2025.
OBJECTIVE
This study explored the clinical efficacy and mechanisms of Mind-Regulating Acupuncture (MRA) for post-stroke depression (PSD) based on the "microbiota-gut-brain axis" theory.
METHODS
92 PSD patients were randomly divided into an observation group (received conventional therapy + MRA) and a control group (conventional therapy only). After 8 weeks of treatment, multiple indicators including depression scores, neurological function scores, and levels of neurotransmitters and gut microbiota were compared.
RESULTS
MRA significantly improved depressive symptoms, neurological function, and daily living abilities in PSD patients. It increased serum 5-HT and BDNF levels, and regulated gut microbiota, promoting beneficial bacteria and reducing harmful ones.
CONCLUSION
MRA effectively treats PSD, and its mechanism may involve regulating the "microbiota-gut-brain axis", increasing beneficial gut bacteria, and enhancing 5-HT and BDNF levels.
目的
本研究基于“微生物群-肠道-脑轴”理论，探讨调神针法治疗脑卒中后抑郁（PSD）的临床疗效及机制。
方法
将92例PSD患者随机分为观察组（接受常规治疗+调神针法）和对照组（仅接受常规治疗）。治疗8周后，比较抑郁评分、神经功能评分、神经递质水平和肠道微生物群等多项指标。
结果
调神针法显著改善了PSD患者的抑郁症状、神经功能和日常生活能力。它提高了血清5-羟色胺（5-HT）和脑源性神经营养因子（BDNF）水平，并调节肠道微生物群，促进有益菌生长，减少有害菌。
结论
调神针法能有效治疗PSD，其机制可能涉及调节“微生物群-肠道-脑轴”，增加肠道有益菌，提高5-HT和BDNF水平。
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