Borecki I B, Rao D C, Lalouel J M, McGue M, Gerrard J W
Genet Epidemiol. 1985;2(4):327-38. doi: 10.1002/gepi.1370020402.
Atopic disease is generally recognized to be familial, although specific genetic components have yet to be identified. High levels of a unique class of immunoglobulins, immunoglobulin E (IgE), have been shown to be associated with allergies. Several investigators have reported evidence indicating a recessive regulatory locus where an individual with the homozygous recessive genotype has persistently elevated levels of IgE. Willcox and Marsh [1978] have proposed a hypothesis relating IgE production and liability to become allergic. A test of this hypothesis was carried out in the present study. Bivariate segregation analysis of IgE levels and allergy was performed on 173 nuclear families, and the results indicate that an IgE regulatory locus contributes to the familial transmission of allergy. The results are further discussed in the context of the Willcox and Marsh hypothesis.
特应性疾病通常被认为具有家族性，尽管尚未确定具体的遗传成分。已证明一类独特的高水平免疫球蛋白，即免疫球蛋白E（IgE），与过敏反应有关。几位研究人员报告了证据，表明存在一个隐性调节基因座，纯合隐性基因型个体的IgE水平持续升高。威尔科克斯和马什[1978年]提出了一个关于IgE产生与过敏易感性的假说。本研究对该假说进行了检验。对173个核心家庭进行了IgE水平和过敏的双变量分离分析，结果表明一个IgE调节基因座促成了过敏的家族性传递。将在威尔科克斯和马什假说的背景下进一步讨论这些结果。
