Meyers D A, Beaty T H, Freidhoff L R, Marsh D G
Am J Hum Genet. 1987 Jul;41(1):51-62.
Since allergic individuals with atopic allergy tend to have higher total serum IgE levels than do nonallergic subjects, family studies of total serum IgE levels are necessary in delineating the genetic and environmental factors involved in the expression of allergic disease. However, previous studies do not agree as to the genetic basis of total IgE production. To try to resolve this conflict, a total of 278 individuals from 42 nuclear families ascertained for large family size (at least four children) were studied. The families were not selected for the presence of allergic disease. Segregation analysis showed that the mixed model of recessive inheritance of high levels was most appropriate for these data--with approximately 36% of the total phenotypic variation in log[IgE] attributable to genetic factors, equally divided between a Mendelian component and a more general polygenic component. Thus, these data suggest some role for Mendelian control of basal IgE levels, but there is significant familial aggregation in IgE levels over and above that due to a Mendelian factor.
由于患有特应性过敏的过敏个体往往比非过敏个体具有更高的血清总IgE水平，因此在描述过敏性疾病表达中涉及的遗传和环境因素时，有必要对血清总IgE水平进行家族研究。然而，先前的研究在总IgE产生的遗传基础方面并未达成一致。为了试图解决这一冲突，对来自42个核心家庭的278名个体进行了研究，这些家庭因家庭规模大（至少四个孩子）而被确定。这些家庭并非因存在过敏性疾病而被选择。分离分析表明，高水平隐性遗传的混合模型最适合这些数据——对数[IgE]中约36%的总表型变异归因于遗传因素，在孟德尔成分和更一般的多基因成分之间平均分配。因此，这些数据表明孟德尔对基础IgE水平的控制有一定作用，但除了孟德尔因素外，IgE水平还存在显著的家族聚集现象。
