体外膜肺氧合成人危重症患者的抗菌药物剂量：叙述性综述
A narrative review on antimicrobial dosing in adult critically ill patients on extracorporeal membrane oxygenation.
机构信息
Division of Public Health, Infectious Diseases and Occupational Medicine, Mayo Clinic, Rochester, MN, USA.
Department of Pharmacy, Mayo Clinic, Rochester, MN, USA.
出版信息
Crit Care. 2024 Oct 4;28(1):326. doi: 10.1186/s13054-024-05101-z.
Abstract
The optimal dosing strategy of antimicrobial agents in critically ill patients receiving extracorporeal membrane oxygenation (ECMO) is unknown. We conducted comprehensive review of existing literature on effect of ECMO on pharmacokinetics and pharmacodynamics of antimicrobials, including antibacterials, antifungals, and antivirals that are commonly used in critically ill patients. We aim to provide practical guidance to clinicians on empiric dosing strategy for these patients. Finally, we discuss importance of therapeutic drug monitoring, limitations of current literature, and future research directions.
摘要
在接受体外膜肺氧合（ECMO）治疗的危重症患者中，抗菌药物的最佳给药策略尚不清楚。我们对现有的关于 ECMO 对抗菌药物、抗真菌药物和抗病毒药物药代动力学和药效学影响的文献进行了全面综述，这些药物是危重症患者常用的药物。我们旨在为临床医生提供这些患者经验性给药策略的实用指导。最后，我们讨论了治疗药物监测的重要性、现有文献的局限性以及未来的研究方向。
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