Cell Biology, University of Kaiserslautern, RPTU, Kaiserslautern, Germany.
FEBS Open Bio. 2024 Oct;14(10):1588-1590. doi: 10.1002/2211-5463.13884.
Mitochondria are essential organelles of eukaryotic cells. They consist of hundreds of proteins, which are synthesized in the cytosol and imported into mitochondria via different targeting routes. In addition, a small number of proteins are encoded by the organellar genome and synthesized by mitochondrial ribosomes. In this 'In the Limelight' special issue of FEBS Open Bio, five review articles describe these different biogenesis routes of mitochondrial proteins and provide a comprehensive overview of the structures and mechanisms by which mitochondrial proteins are synthesized and transported to their respective location within the organelle. These reviews, written by leading experts, provide a general overview, but also highlight current developments in the field of mitochondrial biogenesis.
线粒体是真核细胞的重要细胞器。它们由数百种蛋白质组成，这些蛋白质在细胞质中合成，并通过不同的靶向途径进入线粒体。此外，少数蛋白质由细胞器基因组编码，并由线粒体核糖体合成。在 FEBS Open Bio 的这个“聚光灯下”特刊中，五篇综述文章描述了线粒体蛋白质的这些不同生物发生途径，并全面概述了线粒体蛋白质的合成和运输到细胞器内各自位置的结构和机制。这些由领先专家撰写的评论文章提供了一个总体概述，但也突出了线粒体生物发生领域的当前发展。
