Bannai C, Yamashita K, Kugai N, Koide Y, Akisada M
Horm Metab Res. 1985 Dec;17(12):671-3. doi: 10.1055/s-2007-1013640.
Statistical analysis of relationship between free thyroxine (FT4) and thyroxine (T4) in patients with Graves' disease has revealed that serum FT4 values correlated well with serum T4 values at variable thyroid states before and during treatment with anti-thyroid drugs. However, the ratio of FT4 concentration to T4 concentration at hyperthyroid state was more than twice as large as the ratio at euthyroid and hypothyroid states. These findings are considered to denote the elevation of per cent of FT4 to T4 (% FT4) in thyrotoxicosis. Nevertheless, thyroxine-binding globulin (TBG) concentrations in hyperthyroid patients were slightly, but significantly lower by 7.3% than those in normal euthyroid volunteers. These results indicate the minimal contribution of the slight decrease in TBG concentrations to the marked elevation of %FT4 in patients with thyrotoxicosis.
对格雷夫斯病患者游离甲状腺素（FT4）与甲状腺素（T4）之间关系的统计分析表明，在使用抗甲状腺药物治疗之前和期间的不同甲状腺状态下，血清FT4值与血清T4值密切相关。然而，甲状腺功能亢进状态下FT4浓度与T4浓度的比值是甲状腺功能正常和甲状腺功能减退状态下比值的两倍多。这些发现被认为表明甲状腺毒症中FT4占T4的百分比（%FT4）升高。尽管如此，甲状腺功能亢进患者的甲状腺素结合球蛋白（TBG）浓度比正常甲状腺功能正常的志愿者略低，但显著低7.3%。这些结果表明，TBG浓度的轻微下降对甲状腺毒症患者%FT4的显著升高贡献极小。
