Universidad Tecnológica de Pereira-Audifarma S.A, Pereira, Risaralda, Colombia.
Fundación Universitaria Autónoma de las Américas, Pereira, Risaralda, Colombia.
Inquiry. 2024 Jan-Dec;61:469580241288429. doi: 10.1177/00469580241288429.
Human immunodeficiency virus (HIV) is a global public health problem. Coinfections in HIV patients are frequent complications that increase their mortality. The aim of this study was to assess coinfections and in-hospital mortality in a group of patients infected with HIV in Colombia. A retrospective longitudinal study was carried out. Patients treated in 4 highly complex clinics in Colombia between 2015 and 2023 were included. The cases were identified from International Classification of Diseases codes related to HIV. Sociodemographic, clinical, laboratory and pharmacological variables were collected. Descriptive, bivariate, and multivariable analyses were performed. Of the 249 patients identified, 79.1% were men, and the median age was 38.0 years. Approximately 81.1% had a diagnosis of acquired immune deficiency syndrome (AIDS). Coinfections caused by (24.1%) and (20.5%) were the most frequent. A total of 20.5% of the patients had sepsis, 12.4% had septic shock, and the fatality rate was 15.7%. Antibiotics and antifungals were used in 88.8% and 53.8%, respectively, of the patients. Patients with a diagnosis of HIV before admission, those infected with , and those who presented with sepsis were more likely to die, whereas patients who received antiretroviral agent treatment before admission presented a lower risk. In this study, most HIV patients were in an advanced stage of the disease. Coinfection with was common and was associated with an increased risk of death. Previous HIV diagnosis and sepsis also increased the risk. Approximately half of the patients with a previous HIV diagnosis were receiving antiretroviral therapy and had a better prognosis.
人类免疫缺陷病毒（HIV）是一个全球性的公共卫生问题。HIV 感染者常合并感染，这是导致其死亡率增加的常见并发症。本研究旨在评估在哥伦比亚感染 HIV 的一组患者的合并感染和住院死亡率。这是一项回顾性的纵向研究。研究纳入了 2015 年至 2023 年在哥伦比亚 4 家高度复杂诊所接受治疗的患者。通过与 HIV 相关的国际疾病分类代码识别病例。收集了人口统计学、临床、实验室和药理学变量。进行了描述性、双变量和多变量分析。在所确定的 249 例患者中，79.1%为男性，中位年龄为 38.0 岁。约 81.1%的患者被诊断为获得性免疫缺陷综合征（AIDS）。由 （24.1%）和 （20.5%）引起的合并感染最为常见。共有 20.5%的患者发生脓毒症，12.4%发生感染性休克，死亡率为 15.7%。88.8%的患者使用了抗生素，53.8%的患者使用了抗真菌药物。入院前即被诊断为 HIV 的患者、感染 的患者和发生脓毒症的患者更有可能死亡，而入院前接受抗逆转录病毒药物治疗的患者死亡风险较低。在这项研究中，大多数 HIV 患者处于疾病的晚期。合并感染 很常见，且与死亡风险增加相关。HIV 诊断前和脓毒症也增加了死亡风险。大约一半有 HIV 诊断史的患者正在接受抗逆转录病毒治疗，且预后较好。
