锝氮基团对99mTc放射性药物行为的影响。
Effect of the Tc-nitrido group on the behaviour of 99mTc-radiopharmaceuticals.
作者信息
Baldas J, Bonnyman J
出版信息
Int J Appl Radiat Isot. 1985 Dec;36(12):919-23. doi: 10.1016/0020-708x(85)90247-9.
PMID:3936786
Abstract
The preparation of the 99mTcN-complexes of gluconate, EHDP, HIDA and PIPIDA by substitution reactions of 99mTcNCl4- is described. Studies of the distribution of these complexes in mice indicate that the presence of the Tc-nitrido group significantly alters the biological properties of the 99mTc-complexes formed using these ligands. Results suggest that the 99mTcN-complexes of these ligands are labile and undergo some ligand exchange in vivo.
摘要
描述了通过(^{99m}TcNCl_4^-)的取代反应制备葡萄糖酸盐、EHDP、HIDA和PIPIDA的(^{99m}TcN)配合物。这些配合物在小鼠体内分布的研究表明，锝-氮基的存在显著改变了使用这些配体形成的(^{99m}Tc)配合物的生物学性质。结果表明，这些配体的(^{99m}TcN)配合物不稳定，在体内会发生一些配体交换。
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