Ojha Anupama, Shekhar Shashank, Gupta Poonam, Jaiswal Sonali, Mishra Sarad Kumar
Department of Medical Biochemistry, Mahayogi Gorakhnath University Gorakhpur, Gorakhpur, Uttar Pradesh, India.
Department of Radiotherapy, AIIMS, Gorakhpur, Uttar Pradesh, India.
Discov Oncol. 2024 Oct 5;15(1):526. doi: 10.1007/s12672-024-01235-2.
Cancer is a leading cause of death worldwide, accounting for nearly 10 million deaths in 2020. Reviews indicated a positive relationship between exposure to pesticides and the development of cancers. In the present study, we have estimated the level of oxidative stress markers in serum samples of pesticide exposure and unexposed cancer patients as compared to normal control. We have found a significant decrease in peroxygenase (PON) and arylesterase (ARE) activity and substantial increases in homocysteine levels in both cancer groups. The level of heme biosynthesis rate-limiting enzymes delta-aminolevulinic acid dehydratase (δ-ALA-D) also significantly decreased compared to control. The statistical comparison between the cancer groups does not show significant changes. We concluded the involvement of oxidative stress in carcinogenesis in both cancer group patients. However, more study is needed to put homocysteine as a novel marker for a variety of diseases on a single platform.
癌症是全球主要的死亡原因之一，2020年造成了近1000万人死亡。综述表明，接触杀虫剂与癌症的发生之间存在正相关关系。在本研究中，我们估计了与正常对照组相比，接触杀虫剂的癌症患者和未接触杀虫剂的癌症患者血清样本中的氧化应激标志物水平。我们发现，两个癌症组的过氧化物酶（PON）和芳基酯酶（ARE）活性均显著降低，同型半胱氨酸水平大幅升高。与对照组相比，血红素生物合成限速酶δ-氨基乙酰丙酸脱水酶（δ-ALA-D）的水平也显著降低。癌症组之间的统计比较未显示出显著变化。我们得出结论，氧化应激参与了两个癌症组患者的致癌过程。然而，需要更多的研究将同型半胱氨酸作为多种疾病的新型标志物统一到一个平台上。
