但他林保护角质形成细胞免受颗粒物 2.5 和紫外线 B 引起的损伤。
Butin Protects Keratinocytes From Particulate Matter 2.5 and Ultraviolet B-Mediated Damages.
机构信息
Department of Biochemistry, College of Medicine, Jeju National University, Jeju, Republic of Korea.
Jeju Research Center for Natural Medicine, Jeju National University, Jeju, Republic of Korea.
出版信息
Photodermatol Photoimmunol Photomed. 2024 Nov;40(6):e13001. doi: 10.1111/phpp.13001.
BACKGROUND
Butin is a naturally occurring compound with a wide range of medicinal properties, including anti-inflammatory, anti-arthritic, and antioxidant properties. Particulate matter 2.5 (PM) and ultraviolet B (UVB) radiation contribute to skin cell damage via the induction of oxidative stress.
METHODS
This study sought to assess the protective effects of butin against damage triggered by PM and UVB in human HaCaT keratinocytes. Assessments were performed to evaluate cell viability, apoptosis, and cellular component damage.
RESULTS
Butin exhibited its protective ability via the inhibition of PM-induced reactive oxygen species generation, lipid peroxidation, DNA damage, protein carbonylation, and mitochondrial damage. Butin reduced the PM-induced c-Fos and phospho-c-Jun protein levels as well as mitogen-activated protein kinase. Furthermore, butin mitigated PM- and UVB-induced apoptosis.
CONCLUSION
Butin had the potential as a pharmaceutical candidate for treating skin damage caused by PM and UVB exposure.
背景
布替萘芬是一种天然存在的化合物，具有广泛的药用特性，包括抗炎、抗关节炎和抗氧化特性。细颗粒物 2.5（PM）和紫外线 B（UVB）辐射通过诱导氧化应激导致皮肤细胞损伤。
方法
本研究旨在评估布替萘芬对人 HaCaT 角质形成细胞中由 PM 和 UVB 引发的损伤的保护作用。评估了细胞活力、细胞凋亡和细胞成分损伤。
结果
布替萘芬通过抑制 PM 诱导的活性氧生成、脂质过氧化、DNA 损伤、蛋白质羰基化和线粒体损伤来发挥其保护作用。布替萘芬降低了 PM 诱导的 c-Fos 和磷酸化 c-Jun 蛋白水平以及丝裂原激活蛋白激酶。此外，布替萘芬减轻了 PM 和 UVB 诱导的细胞凋亡。
结论
布替萘芬有潜力成为一种治疗由 PM 和 UVB 暴露引起的皮肤损伤的药物候选物。
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