Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30329, United States.
Clinical Neuroscience Research Unit, Department of Psychiatry, 1 South Prospect Street Arnold 6, Burlington, VT 05401, United States.
Dev Cogn Neurosci. 2024 Dec;70:101461. doi: 10.1016/j.dcn.2024.101461. Epub 2024 Sep 28.
The HEALthy Brain and Child Development (HBCD) study, a multi-site prospective longitudinal cohort study, will examine human brain, cognitive, behavioral, social, and emotional development beginning prenatally and planned through early childhood. The study plans enrolling over 7000 families across 27 sites. This manuscript presents the measures from the Neurocognition and Language Workgroup. Constructs were selected for their importance in normative development, evidence for altered trajectories associated with environmental influences, and predictive validity for child outcomes. Evaluation of measures considered psychometric properties, brevity, and developmental and cultural appropriateness. Both performance measures and caregiver report were used wherever possible. A balance of norm-referenced global measures of development (e.g., Bayley Scales of Infant Development-4) and more specific laboratory measures (e.g., deferred imitation) are included in the HBCD study battery. Domains of assessment include sensory processing, visual-spatial reasoning, expressive and receptive language, executive function, memory, numeracy, adaptive behavior, and neuromotor. Strategies for staff training and quality control procedures, as well as anticipated measures to be added as the cohort ages, are reviewed. The HBCD study presents a unique opportunity to examine early brain and neurodevelopment in young children through a lens that accounts for prenatal exposures, health and socio-economic disparities.
HEALthy 大脑与儿童发育（HBCD）研究是一项多地点前瞻性纵向队列研究，将从产前开始并计划持续到儿童早期，研究人类大脑、认知、行为、社会和情感发育。该研究计划在 27 个地点招募超过 7000 个家庭。本文档介绍了神经认知和语言工作组的测量方法。选择这些方法是因为它们在正常发育中的重要性、与环境影响相关的轨迹改变的证据，以及对儿童结局的预测有效性。评估的方法考虑了心理测量学特性、简洁性以及发展和文化适宜性。HBCD 研究电池组既包括了用于发展的全球标准化参考（例如贝利婴幼儿发展量表第四版），也包括了更具体的实验室测量（例如延迟模仿）。评估的领域包括感觉处理、视觉空间推理、表达和接受性语言、执行功能、记忆、算术、适应行为和神经运动。本文回顾了员工培训和质量控制程序的策略，以及随着队列年龄增长预期增加的措施。HBCD 研究提供了一个独特的机会，通过考虑产前暴露、健康和社会经济差异的视角来研究幼儿的早期大脑和神经发育。
