Department of Pathology, Universidade Estatual de Campinas (Unicamp), Campinas, SP, Brazil.
Hospital de Clínicas da Universidade Estadual de Campinas (Unicamp), Campinas, SP, Brazil.
Clinics (Sao Paulo). 2024 Oct 4;79:100483. doi: 10.1016/j.clinsp.2024.100483. eCollection 2024.
The role of IMP3, CDK4, MDM2 and β-catenin proteins in Enchondroma and Central Chondrosarcoma is not totally understood. The aim of this study is to evaluate the immunoexpression of these proteins, associating histological grade, clinical data and prognosis to these tumors.
This is a retrospective-analytical study of 32 Enchondroma and 70 Central Chondrosarcoma.
IMP3, CDK4, MDM2 and β-catenin expression was observed in 22.82 %, 13.82 %, 17.17 % and in 8.8 % of cases, respectively. All Enchondromas positive for these immunomarkers were located in short tubular bones. The positivity for these antibodies is directly proportional to Chondrosarcoma's histological grade increase. No difference was found between Enchondroma and Chondrosarcoma, Grade 1 for IMP3, CDK4 and ß-catenin positivity. Significant metastasis outcome was observed for IMP3, CDK4, MDM2 and death for MDM2 expression.
IMP3, CDK4, MDM2 and β-catenin expression in Enchondromas of short bones phenotypically characterizes these tumors. Their expression has not proven to be useful either as diagnostic markers of these neoplasms or in distinguishing between Enchondroma and Chondrosarcoma, Grade 1. The significant immunoexpression of IMP3, CDK4 and MDM2 in metastatic Chondrosarcoma and the lower survival in those with positivity for MDM2 suggest a possible association of these proteins with tumor aggressiveness.
IMP3、CDK4、MDM2 和 β-连环蛋白蛋白在软骨瘤和中央性软骨肉瘤中的作用尚未完全阐明。本研究旨在评估这些蛋白的免疫表达，并将组织学分级、临床数据和预后与这些肿瘤相关联。
这是一项回顾性分析研究，纳入了 32 例软骨瘤和 70 例中央性软骨肉瘤。
IMP3、CDK4、MDM2 和 β-连环蛋白的表达率分别为 22.82%、13.82%、17.17%和 8.8%。所有这些免疫标志物阳性的软骨瘤均位于短管状骨。这些抗体的阳性率与软骨肉瘤的组织学分级增加成正比。在 IMP3、CDK4 和β-连环蛋白阳性方面，软骨瘤和 1 级软骨肉瘤之间无差异。IMP3、CDK4、MDM2 的表达与转移结果显著相关，而 MDM2 的表达与死亡相关。
短管状骨软骨瘤中 IMP3、CDK4、MDM2 和 β-连环蛋白的表达表型特征化了这些肿瘤。它们的表达既不能作为这些肿瘤的诊断标志物，也不能用于区分软骨瘤和 1 级软骨肉瘤。在转移性软骨肉瘤中，IMP3、CDK4 和 MDM2 的显著免疫表达，以及 MDM2 阳性患者的生存率较低，提示这些蛋白可能与肿瘤的侵袭性有关。
