Wang Tian, Liu Mingjie, Li Xinyu, Zhang Sen, Gu Haoran, Wei Xuan, Wang Xiaoning, Xu Zhenpeng, Shen Tao
Key Lab of Chemical Biology (MOE), Shandong Engineering Research Center for Traditional Chinese Medicine Standard, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, PR China.
Shandong Center for Food and Drug Evaluation and Inspection, Jinan, Shandong, PR China.
Free Radic Biol Med. 2024 Nov 20;225:560-580. doi: 10.1016/j.freeradbiomed.2024.09.035. Epub 2024 Oct 3.
Cumulative evidence has verified that persistent oxidative stress is involved in the development of various chronic diseases, including pulmonary, neurodegenerative, kidney, cardiovascular, and liver diseases, as well as cancers. Nuclear factor erythroid 2-related factor 2 (Nrf2) plays a pivotal role in regulating cellular oxidative stress and inflammatory reactions, making it a focal point for disease prevention and treatment strategies. Natural products are essential resources for discovering leading molecules for new drug research and development. In this review, we comprehensively outlined the progression of the knowledge on the Nrf2 pathway, Nrf2 activators in clinical trials, the naturally-derived Nrf2 modulators (particularly from 2014-present), as well as their effects on the pathogenesis of chronic diseases.
越来越多的证据证实，持续性氧化应激参与了多种慢性疾病的发展，包括肺部疾病、神经退行性疾病、肾脏疾病、心血管疾病、肝脏疾病以及癌症。核因子红细胞2相关因子2（Nrf2）在调节细胞氧化应激和炎症反应中起关键作用，使其成为疾病预防和治疗策略的重点。天然产物是发现新药研发先导分子的重要资源。在本综述中，我们全面概述了Nrf2信号通路的知识进展、临床试验中的Nrf2激活剂、天然来源的Nrf2调节剂（特别是2014年至今），以及它们对慢性疾病发病机制的影响。
