Department of Psychology, Brandeis University, Waltham, MA, USA.
Trends Neurosci. 2024 Nov;47(11):892-903. doi: 10.1016/j.tins.2024.09.004. Epub 2024 Oct 4.
The monoaminergic nuclei are thought to be some of the earliest sites of Alzheimer's disease (AD) pathology in the brain, with tau-containing pretangles appearing in these nuclei decades before the onset of clinical impairments. It has increasingly been recognized that monoamine systems represent a critical target of investigation towards understanding the progression of AD and designing early detection and treatment approaches. This review synthesizes evidence across animal studies, human neuropathology, and state-of-the-art neuroimaging and daily life assessment methods in humans, which demonstrate robust relationships between monoamine systems and AD pathophysiology and behavior. Further, the review highlights the promise of multimethod, multisystem approaches to studying monoaminergic mechanisms of resilience to AD pathology.
单胺能核被认为是大脑中阿尔茨海默病（AD）病理的最早部位之一，在临床损伤出现前几十年，含有 tau 的预缠结就出现在这些核中。人们越来越认识到，单胺系统是研究 AD 进展和设计早期检测和治疗方法的关键目标。本综述综合了动物研究、人类神经病理学以及最先进的人类神经影像学和日常生活评估方法的证据，这些证据表明单胺能系统与 AD 病理生理学和行为之间存在强有力的关系。此外，该综述强调了采用多方法、多系统研究 AD 病理中单胺能机制的恢复力的前景。
