Buser Genevieve L, Marginean Horia, Dada Mayen, Woodward Savannah, Young Alexis, Chen Chiayi, Tomlinson Mark W
Pediatric Infectious Diseases, Providence St Vincent Medical Center, Portland, OR, USA.
Providence Brain and Spine Institute, Portland, OR, USA.
J Perinatol. 2025 Jan;45(1):122-127. doi: 10.1038/s41372-024-02138-4. Epub 2024 Oct 5.
Determine prevalence of hepatitis C virus (HCV) positivity among postpartum patients to inform prenatal screening recommendations, postpartum connection to care, and infant HCV screening practices.
Convenience sample of postpartum patients at one urban and one suburban hospital to undergo rapid fingerstick testing for hepatitis C antibodies.
Of 2060 postpartum participants successfully screened, 20 (0.97%) had evidence of past or current HCV infection. One co-infection with syphilis occurred. After a median follow-up of 3.75 years, 6 of 12 participants (50.0%) with chronic HCV infection completed treatment with cure, and 9 of 20 infants (45.0%) completed screening. One neonatal transmission event occurred (5.8%).
HCV infection was more common in our postpartum population than other viral infections routinely screened for during pregnancy. Efforts to decrease perinatal HCV transmission should focus on early postpartum connection to treatment team, early screening in infants aged 2-6 months, and pediatric test completion.
确定产后患者丙型肝炎病毒(HCV)阳性的患病率,为产前筛查建议、产后护理衔接及婴儿HCV筛查实践提供依据。
选取一家城市医院和一家郊区医院的产后患者作为便利样本,对其进行丙型肝炎抗体快速指尖检测。
在成功筛查的2060名产后参与者中,20人(0.97%)有既往或当前HCV感染的证据。发生了1例梅毒合并感染。在中位随访3.75年后,12名慢性HCV感染参与者中有6人(50.0%)完成治疗并治愈,20名婴儿中有9人(45.0%)完成筛查。发生了1例新生儿传播事件(5.8%)。
在我们的产后人群中,HCV感染比孕期常规筛查的其他病毒感染更为常见。减少围产期HCV传播的努力应集中在产后早期与治疗团队的衔接、2至6个月龄婴儿的早期筛查以及儿科检测的完成。