左旋咪唑致依赖激素治疗的肾病综合征患儿粒细胞缺乏症：病例报告。
Levamisole Induced Agranulocytosis in a Child with Steroid Dependent Nephrotic Syndrome: A Case Report.
机构信息
Patan Academy of Health Sciences, Lagankhel, Lalitpur, Nepal.
Narayani Upachetriya Hospital, Birjung, Nepal.
出版信息
JNMA J Nepal Med Assoc. 2024 Jul 31;62(276):545-547. doi: 10.31729/jnma.8700.
Levamisole has been used as an effective immunomodulator. Levamisole has been used for nephrotic syndrome due to its immunostimulant, immunomodulating, and steroid-sparing effects. Common adverse effects of levamisole are gastrointestinal symptoms (nausea, abdominal cramps), and pyrexia. However, agranulocytosis or pancytopenia is also a rare but life-threatening complication of levamisole. This is a case report of a 5-year-old girl who had steroid-dependent nephrotic syndrome for which she was started on levamisole as per her weight, following which she had falling total leukocyte count levels on every visit. Thus, this case report emphasizes identifying this rare side effect and its management.
左旋咪唑曾被用作有效的免疫调节剂。由于其具有免疫刺激、免疫调节和类固醇节约作用，左旋咪唑已被用于肾病综合征。左旋咪唑的常见不良反应为胃肠道症状（恶心、腹痛）和发热。然而，粒细胞缺乏症或全血细胞减少症也是左旋咪唑罕见但危及生命的并发症。这是一例 5 岁女孩的病例报告，她患有激素依赖型肾病综合征，根据体重开始使用左旋咪唑，此后每次就诊时总白细胞计数都在下降。因此，本病例报告强调了识别这种罕见的副作用及其管理。
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