Cancer Center, The First Hospital of Jilin University, Changchun, China.
Cancer Center, The First Hospital of Jilin University, Changchun, China.
Ecotoxicol Environ Saf. 2024 Oct 15;285:117143. doi: 10.1016/j.ecoenv.2024.117143. Epub 2024 Oct 5.
The role of environmental factors, particularly air pollutants, in the prevalence of sarcopenia remains unclear.
This study explored the relationship between the prevalence of sarcopenia and prolonged exposure to air pollutants, and investigated potential interactions with genetic susceptibility and inflammation.
Data from 408,117 people at baseline and 35,060 participants in the longitudinal analysis in the UK Biobank were used in this prospective cohort study. Utilizing land use regression models, air pollutants (nitrogen dioxide (NO), nitric oxides (NO), and particulate matter with aerodynamic diameters of ≤2.5 μm (PM) and ≤10 μm (PM) were estimated and classified into quartiles. Alterations in body composition were among the secondary results.
Lastly, 3353 people (0.8 %) developed sarcopenia. Higher levels of air pollutants were linked to an increased prevalence of sarcopenia after controlling for confounding variables (highest vs lowest quartile: NO, OR, 1.21 [95 % CI, 1.16-1.26]; NO, OR, 1.22 [95 % CI, 1.16-1.27]; PM, OR, 1.17 [95 % CI, 1.12-1.22]; PM, OR, 1.15 [95 % CI, 1.10-1.20]; all P<.001). Longitudinal analysis revealed that air pollutants had adverse changes in body composition, including increased muscle fat infiltration and decreased muscle mass. At baseline, the probability of sarcopenia was strongly correlated with NO, NO, PM, and PM, and increased with elevated PRS or CRP levels in subgroup analyses.
Air pollutants may contribute to accelerated muscle aging and highlight the importance of environmental factors in sarcopenia development.
环境因素，尤其是空气污染物，在肌肉减少症的流行中所起的作用尚不清楚。
本研究探讨了肌肉减少症的流行与长期暴露于空气污染物之间的关系，并研究了其与遗传易感性和炎症之间的潜在相互作用。
本前瞻性队列研究使用了英国生物库（UK Biobank）的基线数据（408117 人）和纵向分析（35060 名参与者）。利用土地利用回归模型，对空气污染物（二氧化氮（NO）、一氧化氮（NO）和空气动力学直径≤2.5μm（PM）和≤10μm（PM）的颗粒物）进行了估计和分类，并分为四分位数。身体成分的变化是次要结果之一。
最后，3353 人（0.8%）患上了肌肉减少症。在控制了混杂因素后，较高水平的空气污染物与肌肉减少症的患病率增加有关（最高四分位数与最低四分位数相比：NO，OR，1.21[95%CI，1.16-1.26]；NO，OR，1.22[95%CI，1.16-1.27]；PM，OR，1.17[95%CI，1.12-1.22]；PM，OR，1.15[95%CI，1.10-1.20]；所有 P<.001）。纵向分析显示，空气污染物对身体成分产生了不利变化，包括肌肉脂肪浸润增加和肌肉质量减少。在基线时，NO、NO、PM 和 PM 与肌肉减少症的发生概率呈强烈相关，且在亚组分析中，随着 PRS 或 CRP 水平的升高，肌肉减少症的发生概率也随之增加。
空气污染物可能导致肌肉加速老化，并强调了环境因素在肌肉减少症发展中的重要性。
