Zeng Tao, Liao Xinliang, Wu Jie
Guangdong Provincial Geriatrics Institute, Affiliated Guangdong Provincial People's Hospital of Southern Medical University, Guangdong Academy of Medical Sciences.
Guangdong Provincial People's Hospital Ganzhou Hospital, Ganzhou Municipal Hospital.
Environ Health Prev Med. 2025;30:65. doi: 10.1265/ehpm.24-00280.
Exposure to air pollution and adherence to a healthy lifestyle have been identified to be related to sarcopenia. However, the interactive effects between these two factors remain insufficiently elucidated. The present study was designed to investigate the potential interaction exposure to air pollution with healthy lifestyle on the risk of developing sarcopenia.
In the retrospective cohort study, all data was extracted from China Health and Retirement Longitudinal Study. Household air pollution was assessed based on the utilization of solid fuels for cooking and heating. A lifestyle score was constructed comprising information on physical activity, smoking, drinking and sleeping time. Multivariate logistic regression model was used to assess the effects of household air pollution and healthy lifestyle score on sarcopenia, separately. We further explored the additive interaction between household air pollution and healthy lifestyle score to sarcopenia using the interaction table developed by T Anderson. Relative excess risk due to interaction (RERI), attributable proportion (AP), and synergy index (SI) were used to evaluate the additive interactive effect.
2,114 participants were included in this study. The result indicated that exposed to household air pollution [adjusted relative risk (RR) = 1.80, 95% confidence interval (CI): 1.15-2.94] and unhealthy lifestyle (adjusted RR = 1.46, 95%CI: 1.04-2.03) were both significantly associated with increased risk of sarcopenia. Furthermore, participants exposed to both household air pollution and an unhealthy lifestyle exhibited a significantly higher risk of sarcopenia relative to those without household air pollution exposure and maintaining a healthy lifestyle (adjusted RR = 2.44). But RERI, AP, and SI suggested that there is no statistically significant additive interaction between household air pollution exposure and healthy lifestyle factors in relation to sarcopenia risk.
Household air pollution in conjunction with an unhealthy lifestyle confers a significantly higher risk of sarcopenia compared to either factor in isolation, with no evidence of a significant additive interaction between these two risk factors.
已确定暴露于空气污染和坚持健康生活方式与肌肉减少症有关。然而，这两个因素之间的交互作用仍未得到充分阐明。本研究旨在调查空气污染暴露与健康生活方式对肌肉减少症发生风险的潜在交互作用。
在这项回顾性队列研究中，所有数据均从中国健康与养老追踪调查中提取。基于烹饪和取暖使用固体燃料的情况评估家庭空气污染。构建了一个生活方式评分，包含身体活动、吸烟、饮酒和睡眠时间等信息。使用多变量逻辑回归模型分别评估家庭空气污染和健康生活方式评分对肌肉减少症的影响。我们进一步使用T·安德森开发的交互作用表探讨家庭空气污染和健康生活方式评分与肌肉减少症之间的相加交互作用。使用交互作用所致相对超额危险度（RERI）、归因比例（AP）和协同指数（SI）来评估相加交互作用效果。
本研究纳入了2114名参与者。结果表明，暴露于家庭空气污染[调整后相对危险度（RR）=1.80，95%置信区间（CI）：1.15 - 2.94]和不健康生活方式（调整后RR = 1.46，95%CI：1.04 - 2.03）均与肌肉减少症风险增加显著相关。此外，相对于未暴露于家庭空气污染且保持健康生活方式的参与者，同时暴露于家庭空气污染和不健康生活方式的参与者肌肉减少症风险显著更高（调整后RR = 2.44）。但RERI、AP和SI表明，在肌肉减少症风险方面，家庭空气污染暴露与健康生活方式因素之间不存在统计学上显著的相加交互作用。
与单独的任何一个因素相比，家庭空气污染与不健康生活方式相结合会使肌肉减少症风险显著更高，且没有证据表明这两个风险因素之间存在显著的相加交互作用。
