Grabner G, Schreiner J, Luger T A, Stur M, Huber-Spitzy V
Klin Monbl Augenheilkd. 1985 Nov;187(5):406-7. doi: 10.1055/s-2008-1054349.
Tissue mast cells play a central role in the pathogenesis of allergic eye diseases. In the study reported here the authors investigated whether human corneal epithelial cells and a human epitheloid conjunctival cell line (Chang) can produce an interleukin 3 (IL 3)-like mast cell-activating factor. The activity was detected at a m.w. of 15 and 30 kD, the isoelectric points were located at a pH of 7.85, 7.15 and 6.75. The authors believe that this cytokine, which is produced by epithelial cells of the cornea and conjunctiva, might play an important role in the pathogenesis of allergic ocular diseases.
组织肥大细胞在变应性眼病的发病机制中起核心作用。在本文报道的研究中，作者调查了人角膜上皮细胞和人结膜上皮样细胞系（张氏细胞系）是否能产生一种白细胞介素3（IL-3）样肥大细胞激活因子。该活性在分子量15和30kD处被检测到，其等电点位于pH 7.85、7.15和6.75。作者认为，这种由角膜和结膜上皮细胞产生的细胞因子可能在变应性眼病的发病机制中起重要作用。
