Knöpfle G
Klin Padiatr. 1985 Nov-Dec;197(6):481-8. doi: 10.1055/s-2008-1034026.
Endocrine disorders do not represent primary manifestations in children with cystic fibrosis. Abnormal thyroid gland function is commonly observed in patients with chronic nonthyroidal illnesses. Serum concentrations of TSH, T4 and T3 were measured and a TRH-stimulation test (200 micrograms Relefact per kg body weight) was performed in 24 patients with CF 6 to 16 1/2 years of age. As compared to the controls, CF patients had increased basal TSH and lower T4 and T3 concentrations. Finally they exhibited higher TRH-stimulated TSH and decreased peripheral T4 and T3. There was no correlation to the nutritional status or the Shwachman scores. In all patients with CF albumin, TBG and TBPA were also normal. Our results indicate a subclinical hypothyroidism in CF. Routine therapy with thyroid hormones is neither necessary nor recommended.
内分泌紊乱并非囊性纤维化患儿的主要表现。慢性非甲状腺疾病患者常出现甲状腺功能异常。对24例6至16.5岁的囊性纤维化（CF）患者测定了血清促甲状腺激素（TSH）、甲状腺素（T4）和三碘甲状腺原氨酸（T3）浓度，并进行了促甲状腺激素释放激素（TRH）刺激试验（每公斤体重200微克瑞力肽）。与对照组相比，CF患者基础TSH升高，T4和T3浓度降低。最终，他们表现出TRH刺激后TSH升高，外周T4和T3降低。这与营养状况或施瓦克曼评分无关。所有CF患者的白蛋白、甲状腺素结合球蛋白（TBG）和甲状腺素结合前白蛋白（TBPA）也均正常。我们的结果表明CF患者存在亚临床甲状腺功能减退。既无必要也不建议常规使用甲状腺激素治疗。
