Iziki Hayat, Yakini Souad, Ouabich Raja, Bounabe Abdelaaziz, Doukkani Nezha, Ben-Abjaou Naima, Ben Taleb Sanae, Blaak Hicham, Boutib Amal, Barkat Amina
Higher Institute of Nursing Professions and Health Techniques of Agadir, Agadir, Morocco.
Laboratory of Mother-Child Health and Nutrition Research, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University of Rabat, Rabat, Morocco.
Infect Chemother. 2024 Sep;56(3):361-368. doi: 10.3947/ic.2024.0056.
Human immunodeficiency virus (HIV) infection in children is a significant public health concern, increasing the risk of infant mortality. Immunodeficiency caused by HIV favors the development of opportunistic infections (OIs), which are responsible for over 90% of HIV-related deaths. This study seeks to determine the primary OIs in children with HIV followed at the Hassan II Regional Hospital Center in Sous Massa, during the period from 2012 to 2023.
This retrospective study is the first in Morocco to investigate OIs among HIV-infected children. It analyzed 76 complete medical records, using a data collection form designed based on existing literature.
This study revealed that 37% of participants were suffering from OIs, mainly diarrhea (11%), tuberculosis (9%) and pneumonia (7%).There was a significant correlation between OIs and HIV clinical stage (0.001), age (=0.007), and anemia (=0.001). Despite progress in management, the presence of OIs remains a risk factor for infant morbidity and mortality.
The study highlights the importance of early detection, prevention, and adherence to treatment in reducing this burden. Management of anemia is essential.
儿童感染人类免疫缺陷病毒（HIV）是一个重大的公共卫生问题，增加了婴儿死亡率。HIV 引起的免疫缺陷有利于机会性感染（OIs）的发展，OIs 导致了超过 90%的与 HIV 相关的死亡。本研究旨在确定 2012 年至 2023 年期间在苏斯马萨的哈桑二世地区医院中心接受随访的 HIV 感染儿童中的主要机会性感染。
这项回顾性研究是摩洛哥首次对 HIV 感染儿童中的机会性感染进行调查。它使用基于现有文献设计的数据收集表分析了 76 份完整的医疗记录。
本研究显示，37%的参与者患有机会性感染，主要是腹泻（11%）、结核病（9%）和肺炎（7%）。机会性感染与 HIV 临床分期（0.001）、年龄（=0.007）和贫血（=0.001）之间存在显著相关性。尽管在管理方面取得了进展，但机会性感染的存在仍然是婴儿发病和死亡的一个危险因素。
该研究强调了早期检测、预防和坚持治疗在减轻这一负担方面的重要性。贫血的管理至关重要。
