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PD 相关非运动症状的诊断和治疗挑战:神经科医生和会诊医师的作用。

Diagnostic and therapeutic challenges in PD-associated non-motor symptoms: the roles of neurologists and consultant physicians.

机构信息

Dept. of Neurology, University Hospital of Würzburg, Würzburg, Germany.

Dept. of Neurology, University Hospital Ulm, Ulm, Germany.

出版信息

J Neural Transm (Vienna). 2024 Oct;131(10):1263-1273. doi: 10.1007/s00702-024-02838-3. Epub 2024 Oct 7.

Abstract

In addition to their motor symptoms, almost all Parkinson's disease patients report non-motor symptoms (NMS) and, in the later course of the disease, non-motor fluctuations as well. These NMS encompass e.g. neuropsychiatric, gastrointestinal, urogenital, cardiovascular symptoms and pain. For a long time, these symptoms received no or at best very little attention, but there is a growing trend towards their recognition and treatment. Despite this progress, significant gaps remain, particularly due to the sometimes-limited expertise among neurologists regarding these symptoms. The clinical need to consequently treat these NMS raises the question of whether Movement Disorder specialists should and can address them sufficiently or if additional consultant physicians have to be enrolled. Therefore, our objective is to establish benchmarking criteria to outline a potential way forward. Ideally, Movement Disorder specialists should take on greater responsibility when treating non-motor PD symptoms, integrating diagnostic and therapeutic pathways from other medical disciplines where feasible.

摘要

除了运动症状外,几乎所有帕金森病患者都报告存在非运动症状(NMS),而且在疾病后期还会出现非运动波动。这些 NMS 包括神经精神、胃肠道、泌尿生殖、心血管症状和疼痛等。长期以来,这些症状要么没有得到关注,要么最多只是得到了很少的关注,但现在越来越重视对它们的识别和治疗。尽管取得了这一进展,但仍存在显著差距,特别是由于神经科医生对这些症状的专业知识有时有限。因此,临床需要对这些 NMS 进行治疗,这就提出了一个问题,即运动障碍专家是否应该而且能够充分解决这些问题,或者是否需要聘请其他顾问医生。因此,我们的目标是建立基准标准,以勾勒出一个潜在的前进方向。理想情况下,运动障碍专家在治疗非运动性帕金森病症状时应承担更大的责任,尽可能整合来自其他医学学科的诊断和治疗途径。

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