Chen Ming-An, Yang Yuan-Han, Liu Ching-Kuan, Matsuo Koichiro, Hsu Chih-Cheng, Lin Ying-Chu, Huang Hsiao-Ling
School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Department of Oral Hygiene, Shu-Zen Junior College of Medicine and Management, Kaohsiung, Taiwan.
J Oral Rehabil. 2025 Jan;52(1):1-8. doi: 10.1111/joor.13867. Epub 2024 Oct 6.
Emerging evidence suggests a link between salivary metabolite changes and neurodegenerative dementia, with antimicrobial peptides (AMPs) implicated in its pathogenesis.
We investigated the effects of a clinical oral rehabilitation programme tailored for dementia patients on salivary flow rate, AMP levels and oral health-related quality of life (OHRQoL).
Eligible patients were randomly assigned to either the experimental group (EG; n = 28) or the control group (CG; n = 27). Both groups received a leaflet on oral health. In addition, the EG received an oral care intervention that included individual lessons on oral muscle exercises and oral self-care practices. Saliva samples and OHRQoL data were collected at baseline and follow-up visits. Generalised estimating equation models were used to analyse the changes over time.
At the 3-month follow-up, EG showed significantly lower histatin 5 (HTN-5) levels (β = -0.08; effect size [ES] = 0.72) than CG. At 6 months, EG exhibited improved salivary flow rate (β = 0.89; ES = 0.89) and OHRQoL (β = 6.99; ES = 1.31) compared to CG. Changes in salivary flow rate (β = 4.03), HTN-5 level (β = -0.78) and beta-defensin 2 level (BD-2) (β = -0.91) at 3 months predicted improved OHRQoL at 6 months (all p < 0.05).
Our clinical oral rehabilitation programme reduced the level of salivary HTN-5, increased salivary flow rate and enhanced OHRQoL in dementia patients. Furthermore, changes in salivary flow rate, HTN-5 level and BD-2 level were associated with improvements in patients' OHRQoL.
新出现的证据表明唾液代谢物变化与神经退行性痴呆之间存在联系，抗菌肽（AMPs）涉及其发病机制。
我们研究了针对痴呆患者量身定制的临床口腔康复计划对唾液流速、AMP水平和口腔健康相关生活质量（OHRQoL）的影响。
符合条件的患者被随机分配到实验组（EG；n = 28）或对照组（CG；n = 27）。两组均收到一份口腔健康宣传册。此外，EG接受了口腔护理干预，包括口腔肌肉锻炼和口腔自我护理实践的个别课程。在基线和随访时收集唾液样本和OHRQoL数据。使用广义估计方程模型分析随时间的变化。
在3个月的随访中，EG的组蛋白5（HTN-5）水平显著低于CG（β = -0.08；效应大小[ES] = 0.72）。在6个月时，与CG相比，EG的唾液流速（β = 0.89；ES = 0.89）和OHRQoL（β = 6.99；ES = 1.31）有所改善。3个月时唾液流速（β = 4.03）、HTN-5水平（β = -0.78）和β-防御素2水平（BD-2）（β = -0.91）的变化预测了6个月时OHRQoL的改善（所有p < 0.05）。
我们的临床口腔康复计划降低了痴呆患者唾液HTN-5水平，增加了唾液流速，提高了OHRQoL。此外，唾液流速、HTN-5水平和BD-2水平的变化与患者OHRQoL的改善有关。
