Photoredox/Copper-Cocatalyzed Domino Annulation of Oxime Esters and NHSCN: Access to Fully Substituted 2-Aminothiazoles.

Domino cyclization of oxime esters and NHSCN facilitated by photoredox and copper cocatalysis has been established. Various structurally diverse fully substituted 2-aminothiazoles have been obtained in good yields at room temperature. It is featured by mild conditions, favorable functional group tolerance, and wide substrate scope. The present reaction is amenable to gram-scale synthesis, which is expected to find potential applications in organic synthesis and drug discovery. A plausible reaction mechanism is proposed.