钯（II）/路易斯酸共催化 2-烯基苯胺和炔丙基酯的氧化环化反应：苯并[ ]氮杂卓的合成方法。
Palladium(II)/Lewis Acid Cocatalyzed Oxidative Annulation of 2-Alkenylanilines and Propargylic Esters: An Access to Benzo[]azepines.
机构信息
Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, National Demonstration Center for Experimental Chemistry Education, College of Chemistry & Materials Science , Northwest University , 1 Xuefu Road , Xi'an , Shaanxi 710127 , P. R. China.
Shaanxi Key Laboratory of Low Rank Coal Pyrolysis, Shaanxi Coal and Chemical Technology Institute Co., Ltd., State Energy Key Lab of Clean Coal Grading Conversion Modern Chemical Technology Department , 2 Jinye Road , Xi'an , Shaanxi 710065 , P. R. China.
出版信息
J Org Chem. 2019 Sep 6;84(17):10843-10851. doi: 10.1021/acs.joc.9b01406. Epub 2019 Aug 20.
An attractive approach to valuable yet synthetically challenging benzo[]azepines was established via palladium(II)/Lewis acid cocatalyzed oxidative [5 + 2] annulation of readily available 2-alkenylanilines and propargylic esters. The protocol features mild reaction conditions and good functional group tolerance, constituting an array of benzo[]azepines in yields of 30-75%.
通过钯（II）/路易斯酸协同催化的易得的 2-烯基苯胺和炔丙基酯的氧化[5 + 2]环化反应，建立了一种有吸引力的合成具有挑战性的苯并[azepine]的方法。该方案具有温和的反应条件和良好的官能团耐受性，在 30-75%的收率下构成了一系列苯并[azepine]。
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