Altenburg Ilse S, Smets Nina G, Strijkers Gustav J, Bakker Erik Ntp
Department of Biomedical Engineering and Physics, Amsterdam University Medical Center, Amsterdam, The Netherlands.
Amsterdam Cardiovascular Sciences Research Institute, Amsterdam, The Netherlands.
J Cereb Blood Flow Metab. 2024 Dec;44(12):1403-1408. doi: 10.1177/0271678X241289772. Epub 2024 Oct 7.
Medin is a protein fragment derived from milk fat globule epidermal growth factor VIII (MFG-E8). Medin aggregates are present in the vessel wall of most subjects over 50 years of age. In this narrative review, we focus on the consequences of medin aggregation in relation to the development of dementia. Recent literature revealed medin as biomarker for dementia in CSF, specifically of a vascular subtype. Preclinical work showed that medin is associated with aging-related cerebral vascular dysfunction, vascular stiffening, hypertension, and. vascular amyloid β deposition. These findings position medin as a potential mechanistic link between aging, vascular pathology and dementia.
Medin是一种源自乳脂肪球表皮生长因子VIII（MFG-E8）的蛋白质片段。Medin聚集体存在于大多数50岁以上受试者的血管壁中。在这篇叙述性综述中，我们关注Medin聚集与痴呆症发展相关的后果。最近的文献表明，Medin是脑脊液中痴呆症的生物标志物，特别是血管亚型的生物标志物。临床前研究表明，Medin与衰老相关的脑血管功能障碍、血管硬化、高血压以及血管淀粉样β沉积有关。这些发现将Medin定位为衰老、血管病理和痴呆症之间潜在的机制联系。
