Kushwaha Preeti, Saxena Anjali, von Münchow Tristan, Dana Suman, Saha Biswajit, Ackermann Lutz
Amity Institute of Click chemistry Research & Studies, Amity University, Noida, 201303, Uttar Pradesh, India.
Amity Institute of Biotechnology, Amity University, Noida, 201303, Uttar Pradesh, India.
Chem Commun (Camb). 2024 Oct 22;60(85):12333-12364. doi: 10.1039/d4cc03871a.
Alkyne annulation represents a versatile and powerful strategy for the assembly of structurally complex compounds. Recent advances successfully enabled electrocatalytic alkyne annulations, significantly expanding the potential applications of this promising technique towards sustainable synthesis. The metallaelectro-catalyzed C-H activation/annulation stands out as a highly efficient approach that leverages electricity, combining the benefits of electrosynthesis with the power of transition-metal catalyzed C-H activation. Particularly attractive is the pairing of the electro-oxidative C-H activation with the valuable hydrogen evolution reaction (HER), thereby addressing the growing demand for green energy solutions. Herein, we provide an overview of the evolution of electrochemical C-H annulations with alkynes for the construction of heterocycles, with a topical focus on the underlying mechanism manifolds.
炔烃环化反应是构建结构复杂化合物的一种通用且强大的策略。最近的进展成功实现了电催化炔烃环化反应，极大地扩展了这一有前景的技术在可持续合成方面的潜在应用。金属电催化的C-H活化/环化反应作为一种高效方法脱颖而出，它利用电能，将电合成的优势与过渡金属催化的C-H活化的能力相结合。特别吸引人的是将电氧化C-H活化与有价值的析氢反应（HER）配对，从而满足对绿色能源解决方案日益增长的需求。在此，我们概述了用于构建杂环的电化学C-H与炔烃环化反应的发展历程，重点关注其潜在的机理类型。
