Loosen P T, Youngblood W, Dew B
Pharmacopsychiatry. 1985 Nov;18(6):325-9. doi: 10.1055/s-2007-1017390.
Plasma levels of exogenous TRH were measured in eleven normal subjects. They were assessed as to their possible associations with the TRH disappearance rate in vivo, with the TSH and prolactin response, and with the behavioral (and side) effects of TRH. Max. levels of plasma TRH occurred consistently two minutes after injection of TRH (0.5 mg). They ranged from 8.1 to 75.1 ng/ml and were negatively correlated with the in vivo TRH disappearance rate. The latter, in turn, was positively correlated with such factors as height and body surface. Max. plasma TRH levels were not related to the magnitude of the TSH or prolactin response, or to the occurrence of behavioral effects. Nor were they related to the TRH-induced side effects although these effects occurred during the time of increasing TRH plasma levels.
对11名正常受试者的血浆中外源性促甲状腺激素释放激素（TRH）水平进行了测定。评估了它们与体内TRH消失率、促甲状腺激素（TSH）和催乳素反应以及TRH的行为（和副作用）效应之间可能存在的关联。注射TRH（0.5毫克）后两分钟，血浆TRH水平始终达到最大值。其范围为8.1至75.1纳克/毫升，并且与体内TRH消失率呈负相关。而体内TRH消失率又与身高和体表面积等因素呈正相关。血浆TRH的最大水平与TSH或催乳素反应的幅度无关，也与行为效应的发生无关。它们也与TRH诱导的副作用无关，尽管这些副作用在血浆TRH水平升高期间出现。
