Sunderland T, Tariot P N, Mueller E A, Newhouse P A, Murphy D L, Cohen R M
Psychiatry Res. 1985 Dec;16(4):269-75. doi: 10.1016/0165-1781(85)90118-0.
Dementia of the Alzheimer type (DAT) is known to be a heterogeneous syndrome with many clinical manifestations, including depression. In the present study, the thyrotropin-releasing hormone (TRH) stimulation test, previously used as a possible biological marker of depression, was administered to 15 DAT patients and 10 elderly controls. Seven out of 15 (47%) of the patients but none of the controls showed a blunted response with maximal changes of thyroid-stimulating hormone (TSH) from baseline of less than or equal to 7 microIU/ml following injection of 500 micrograms of TRH. The degree of blunting did not correlate with concurrent depression ratings.
阿尔茨海默型痴呆（DAT）是一种具有多种临床表现的异质性综合征，包括抑郁。在本研究中，对15名DAT患者和10名老年对照者进行了促甲状腺激素释放激素（TRH）刺激试验，该试验以前曾被用作抑郁的一种可能的生物学标志物。15名患者中有7名（47%）出现反应迟钝，注射500微克TRH后促甲状腺激素（TSH）从基线的最大变化小于或等于7微国际单位/毫升，而对照者中无人出现这种情况。反应迟钝的程度与同时期的抑郁评分无关。
