伴有或不伴有抑郁症的酒精依赖患者对促甲状腺激素释放激素的血清促甲状腺激素反应。

Serum thyrotropin responses to thyrotropin-releasing hormone in alcohol-dependent patients with and without depression.

作者信息

O'Hanlon M, Barry S, Clare A W, Dinan T G

机构信息

St. Patrick's Hospital, Dublin, Ireland.

出版信息

J Affect Disord. 1991 Feb;21(2):109-15. doi: 10.1016/0165-0327(91)90057-y.

DOI:10.1016/0165-0327(91)90057-y

PMID:1827638

Abstract

Forty-one patients with DSM-III alcohol dependence syndrome were studied, as were 30 patients with major depression and 20 healthy controls. Nineteen of the alcohol-dependent patients had depressive symptoms. All subjects underwent a TRH/TSH stimulation test. Fifty percent of the alcohol-dependent patients without depression had a blunted response, while 52% of patients with depression were similarly blunted. The overall rate of blunting in the non-alcoholic major depressives was 26%. Blunting in the alcoholics was not associated with a personal or family history of affective disorder. Furthermore the blunted response in recently detoxified alcoholics was of no prognostic significance.

摘要

对41例患有DSM-III酒精依赖综合征的患者、30例重度抑郁症患者和20名健康对照者进行了研究。19名酒精依赖患者有抑郁症状。所有受试者均接受了促甲状腺激素释放激素/促甲状腺激素刺激试验。50% 无抑郁症状的酒精依赖患者反应迟钝，而52% 有抑郁症状的患者同样反应迟钝。非酒精性重度抑郁症患者的总体反应迟钝率为26%。酗酒者的反应迟钝与情感障碍的个人或家族史无关。此外，近期戒酒的酗酒者反应迟钝并无预后意义。