DL-多巴给药后，脑儿茶酚胺水平的变化不会因氘取代而增强。

Changes in brain catecholamine levels following DL-dopa are not potentiated by deuterium substitution.

作者信息

Dewar K M, Dyck L E, Durden D A, Boulton A A

出版信息

Prog Neuropsychopharmacol Biol Psychiatry. 1985;9(5-6):675-80. doi: 10.1016/0278-5846(85)90039-9.

Abstract

Adult male Wistar rats were treated with either DL-dopa, D3-DL-dopa or vehicle and sacrificed at various time intervals after treatment. Brain dopamine and noradrenaline concentrations were measured using quantitative mass spectrometric analysis. After treatment with DL-dopa or D3-DL-dopa, total dopamine levels increased above control values; however, no differences were observed between the two drug treatments. Total noradrenaline levels were not significantly altered by treatment with either DL-dopa or D3-DL-dopa. Deuterium substitution did not appear to affect catecholamine deamination or beta-hydroxylation in vivo.

摘要

成年雄性Wistar大鼠分别用DL-多巴、D3-DL-多巴或赋形剂处理，并在处理后的不同时间间隔处死。使用定量质谱分析法测量脑内多巴胺和去甲肾上腺素浓度。用DL-多巴或D3-DL-多巴处理后，总多巴胺水平高于对照值；然而，两种药物处理之间未观察到差异。用DL-多巴或D3-DL-多巴处理均未显著改变总去甲肾上腺素水平。氘取代似乎不影响体内儿茶酚胺的脱氨基作用或β-羟基化作用。