Stepanović S R, Nikolić J
Experientia. 1983 Sep 15;39(9):1050-1. doi: 10.1007/BF01989800.
The effect of a mixture of l-DOPA and benserazide on the amount of dopamine in the corpus striatum of rats irradiated with 850 R of X-rays was investigated. The amount of dopamine in the corpus striatum was measured fluorimetrically at various times after irradiation. It was found that i.p. administration of l-DOPA and benserazide 1,2 and 5 days after irradiation produces significant replenishment of dopamine in the striatum, thus indicating that precursor uptake and metabolism, and probably amine storage, remained unaltered after irradiation.
研究了左旋多巴和苄丝肼混合物对受850伦琴X射线照射的大鼠纹状体中多巴胺含量的影响。在照射后的不同时间，用荧光法测量纹状体中的多巴胺含量。结果发现，在照射后第1、2和5天腹腔注射左旋多巴和苄丝肼可使纹状体中的多巴胺显著补充，这表明照射后前体摄取和代谢以及可能的胺储存未发生改变。
