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胰高血糖素样肽-1 受体激动剂在肿瘤性疾病中的应用。

Glucagon-like peptide-1 receptor agonists in neoplastic diseases.

机构信息

Sinopharm Dongfeng General Hospital (Hubei Clinical Research Center of Hypertension), Hubei Key Laboratory of Wudang Local Chinese Medicine Research, Hubei University of Medicine, Shiyan, China.

Children's Medical Center, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, China.

出版信息

Front Endocrinol (Lausanne). 2024 Sep 20;15:1465881. doi: 10.3389/fendo.2024.1465881. eCollection 2024.

DOI:10.3389/fendo.2024.1465881
PMID:39371922
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11449759/
Abstract

Glucagon-like peptide-1 receptor agonist (GLP-1RA), a novel hypoglycemic agent for the treatment of type 2 diabetes, has well-known effects such as lowering blood sugar, ameliorating inflammation, reducing weight, and lowering blood lipids. It has also been shown that it can influence the proliferation and survival of cells and has a certain effect on the prognosis of some neoplastic diseases. In this study, the potential effects of GLP-1RAs on the occurrence and development of tumors were reviewed to provide new ideas for the prevention and treatment of tumors in patients.

摘要

胰高血糖素样肽-1 受体激动剂(GLP-1RA)是一种新型的降血糖药物,可用于治疗 2 型糖尿病,具有降低血糖、改善炎症、减轻体重和降低血脂等众所周知的作用。此外,它还可以影响细胞的增殖和存活,并对某些肿瘤疾病的预后有一定影响。本研究旨在探讨 GLP-1RAs 对肿瘤发生发展的潜在影响,为患者肿瘤的预防和治疗提供新思路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cef4/11449759/041678bfe705/fendo-15-1465881-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cef4/11449759/041678bfe705/fendo-15-1465881-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cef4/11449759/041678bfe705/fendo-15-1465881-g001.jpg

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本文引用的文献

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GLP-1 RA Improves Diabetic Retinopathy by Protecting the Blood-Retinal Barrier through GLP-1R-ROCK-p-MLC Signaling Pathway.GLP-1RA 通过 GLP-1R-ROCK-p-MLC 信号通路改善糖尿病视网膜病变。
J Diabetes Res. 2022 Nov 3;2022:1861940. doi: 10.1155/2022/1861940. eCollection 2022.
2
GLP-1 Receptor Agonists and the Risk of Thyroid Cancer.胰高血糖素样肽-1受体激动剂与甲状腺癌风险
Diabetes Care. 2023 Feb 1;46(2):384-390. doi: 10.2337/dc22-1148.
3
Combined treatment with glucagon-like peptide-1 receptor agonist exendin-4 and metformin attenuates breast cancer growth.
胰高血糖素样肽-1受体激动剂艾塞那肽-4与二甲双胍联合治疗可减弱乳腺癌生长。
Diabetol Int. 2021 Nov 25;13(3):480-492. doi: 10.1007/s13340-021-00560-z. eCollection 2022 Jul.
4
Review article: role of glucagon-like peptide-1 receptor agonists in non-alcoholic steatohepatitis, obesity and diabetes-what hepatologists need to know.综述文章:胰高血糖素样肽-1 受体激动剂在非酒精性脂肪性肝炎、肥胖和糖尿病中的作用——肝病学家需要了解的知识。
Aliment Pharmacol Ther. 2022 Apr;55(8):944-959. doi: 10.1111/apt.16794. Epub 2022 Mar 9.
5
Cardiovascular and Renal Effectiveness of GLP-1 Receptor Agonists vs. Other Glucose-Lowering Drugs in Type 2 Diabetes: A Systematic Review and Meta-Analysis of Real-World Studies.胰高血糖素样肽-1受体激动剂与其他降糖药物对2型糖尿病患者心血管和肾脏的有效性:一项真实世界研究的系统评价和荟萃分析
Metabolites. 2022 Feb 15;12(2):183. doi: 10.3390/metabo12020183.
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