Department of Nephrology, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Front Endocrinol (Lausanne). 2024 Sep 20;15:1441415. doi: 10.3389/fendo.2024.1441415. eCollection 2024.
In recent years, with the rapid development of omics technologies, researchers have shown that interactions between the intestinal flora and bile acids are closely related to the progression of diabetic kidney disease (DKD). By regulating bile acid metabolism and receptor expression, the intestinal flora affects host metabolism, impacts the immune system, and exacerbates kidney injury in DKD patients. To explore interactions among the gut flora, bile acids and DKD, as well as the related mechanisms, in depth, in this paper, we review the existing literature on correlations among the gut flora, bile acids and DKD. This review also summarizes the efficacy of bile acids and their receptors as well as traditional Chinese medicines in the treatment of DKD and highlights the unique advantages of bile acid receptors in DKD treatment. This paper is expected to reveal a new and important potential strategy for the clinical treatment of DKD.
近年来，随着组学技术的快速发展，研究人员表明肠道菌群与胆汁酸之间的相互作用与糖尿病肾病（DKD）的进展密切相关。肠道菌群通过调节胆汁酸代谢和受体表达，影响宿主代谢，作用于免疫系统，从而加重 DKD 患者的肾脏损伤。为深入探讨肠道菌群、胆汁酸与 DKD 之间的相互作用及其相关机制，本文就肠道菌群、胆汁酸与 DKD 之间相关性的相关文献进行综述，总结胆汁酸及其受体在 DKD 治疗中的作用，并重点阐述胆汁酸受体在 DKD 治疗中的独特优势。本文旨在为 DKD 的临床治疗提供新的潜在策略。
