关于2型糖尿病肠道微生物群的系统评价。
A systematic review on gut microbiota in type 2 diabetes mellitus.
作者信息
Chong Serena, Lin Mike, Chong Deborah, Jensen Slade, Lau Namson S
机构信息
South West Sydney Limb Preservation and Wound Research, Ingham Institute for Applied Medical Research, Sydney, NSW, Australia.
South West Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
出版信息
Front Endocrinol (Lausanne). 2025 Jan 17;15:1486793. doi: 10.3389/fendo.2024.1486793. eCollection 2024.
AIMS/HYPOTHESIS: The gut microbiota play crucial roles in the digestion and degradation of nutrients, synthesis of biological agents, development of the immune system, and maintenance of gastrointestinal integrity. Gut dysbiosis is thought to be associated with type 2 diabetes mellitus (T2DM), one of the world's fastest growing diseases. The aim of this systematic review is to identify differences in the composition and diversity of the gut microbiota in individuals with T2DM.
METHODS
A systematic search was conducted to identify studies reporting on the difference in gut microbiota composition between individuals with T2DM and healthy controls. Relevant studies were evaluated, and their characteristics and results were extracted using a standardized data extraction form. The studies were assessed for risk of bias and their findings were reported narratively.
RESULTS
58 observational studies published between 2010 and 2024 were included. Beta diversity was commonly reported to be different between individuals with T2DM and healthy individuals. Genera Lactobacillus, Escherichia-Shigella, Enterococcus, Subdoligranulum and Fusobacteria were found to be positively associated; while Akkermansia, Bifidobacterium, Bacteroides, Roseburia, Faecalibacteirum and Prevotella were found to be negatively associated with T2DM.
CONCLUSIONS
This systematic review demonstrates a strong association between T2DM and gut dysbiosis, as evidenced by differential microbial abundances and altered diversity indices. Among these taxa, is consistently associated with T2DM, whereas appears to offer a protective effect against T2DM. However, the heterogeneity and observational nature of these studies preclude the establishment of causative relationships. Future research should incorporate age, diet and medication-matched controls, and include functional analysis of these gut microbes.
SYSTEMATIC REVIEW REGISTRATION
https://www.crd.york.ac.uk/prospero/, identifier CRD42023459937.
目的/假设：肠道微生物群在营养物质的消化和降解、生物制剂的合成、免疫系统的发育以及胃肠道完整性的维持中发挥着关键作用。肠道生态失调被认为与2型糖尿病（T2DM）有关，T2DM是全球增长最快的疾病之一。本系统评价的目的是确定T2DM患者肠道微生物群在组成和多样性上的差异。
方法
进行系统检索，以识别报告T2DM患者与健康对照者肠道微生物群组成差异的研究。对相关研究进行评估，并使用标准化数据提取表提取其特征和结果。评估这些研究的偏倚风险，并对其结果进行叙述性报告。
结果
纳入了2010年至2024年发表的58项观察性研究。通常报道T2DM患者与健康个体之间的β多样性存在差异。发现乳酸杆菌属、大肠埃希菌-志贺菌属、肠球菌属、亚多颗粒菌属和梭杆菌属呈正相关；而阿克曼菌属、双歧杆菌属、拟杆菌属、罗斯氏菌属、粪杆菌属和普雷沃菌属与T2DM呈负相关。
结论
本系统评价表明T2DM与肠道生态失调之间存在密切关联，微生物丰度差异和多样性指数改变证明了这一点。在这些分类群中， 始终与T2DM相关，而 似乎对T2DM具有保护作用。然而，这些研究的异质性和观察性质妨碍了因果关系的确立。未来的研究应纳入年龄、饮食和药物匹配的对照，并包括对这些肠道微生物的功能分析。
系统评价注册
Zotero 插件