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黄病毒会操纵线粒体过程以逃避先天免疫反应。

Flaviviruses manipulate mitochondrial processes to evade the innate immune response.

作者信息

Boytz RuthMabel, Keita Kadiatou, Pawlak Joanna B, Laurent-Rolle Maudry

机构信息

Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT USA.

Department of Immunobiology, Yale University School of Medicine, New Haven, CT USA.

出版信息

Npj Viruses. 2024;2(1):47. doi: 10.1038/s44298-024-00057-x. Epub 2024 Oct 4.

DOI:10.1038/s44298-024-00057-x
PMID:39371935
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11452341/
Abstract

Mitochondria are essential eukaryotic organelles that regulate a range of cellular processes, from metabolism to calcium homeostasis and programmed cell death. They serve as essential platforms for antiviral signaling proteins during the innate immune response to viral infections. Mitochondria are dynamic structures, undergoing frequent fusion and fission processes that regulate various aspects of mitochondrial biology, including innate immunity. Pathogens have evolved sophisticated mechanisms to manipulate mitochondrial morphology and function to facilitate their replication. In this review, we examine the emerging literature on how flaviviruses modulate mitochondrial processes.

摘要

线粒体是真核生物必不可少的细胞器，可调节一系列细胞过程，从新陈代谢到钙稳态和程序性细胞死亡。在对病毒感染的先天免疫反应中，它们作为抗病毒信号蛋白的重要平台。线粒体是动态结构，经常经历融合和裂变过程，这些过程调节线粒体生物学的各个方面，包括先天免疫。病原体已经进化出复杂的机制来操纵线粒体的形态和功能以促进其复制。在这篇综述中，我们研究了关于黄病毒如何调节线粒体过程的最新文献。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc8b/11721083/4e81d8779a66/44298_2024_57_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc8b/11721083/2598dbc5fdc9/44298_2024_57_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc8b/11721083/0cc2c2da2dfb/44298_2024_57_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc8b/11721083/1bc3237946fe/44298_2024_57_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc8b/11721083/4e81d8779a66/44298_2024_57_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc8b/11721083/2598dbc5fdc9/44298_2024_57_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc8b/11721083/0cc2c2da2dfb/44298_2024_57_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc8b/11721083/1bc3237946fe/44298_2024_57_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc8b/11721083/4e81d8779a66/44298_2024_57_Fig4_HTML.jpg

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