Tang Huihao, Li Jianzhou, Jin Mengyu, Li Chengliang, Zhai Chuntao, Wang Juan, Huang Taomin, Ding Xiaolei
Institute of Geriatrics, Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, Nantong, China.
Shanghai Engineering Research Center of Organ Repair, School of Medicine, Shanghai University, Shanghai, China.
Front Nutr. 2024 Sep 20;11:1423524. doi: 10.3389/fnut.2024.1423524. eCollection 2024.
Caloric restriction (CR) stands out as one of the most potent interventions that prolong lifespan and mitigate age-associated diseases. Despite its well-established systemic effects, the impact of CR on skin physiological function remains poorly understood, and whether the intervention can alleviate the progression of inflammatory skin diseases remains uncertain. Here, we investigated the effects of CR on mouse skin barrier function and inflammatory response. Our results revealed that CR led to dramatic atrophy in the skin subcutaneous layer. The expression of barrier proteins and trans-epidermal water loss remain largely unchanged. Intriguingly, skin from CR mice exhibited reduced expression of inflammatory cytokines under steady conditions. In an imiquimod (IMQ)-induced mouse model of psoriasis, CR treatment attenuated the pathogenesis of psoriasis phenotypes, accompanied by a reduced activation of mTOR signaling in the psoriatic skin. Taken together, our findings shed light on the complex interplay between metabolic interventions and skin health, suggesting that CR has the potential to serve as a modulator of inflammatory responses in the skin.
热量限制（CR）是延长寿命和减轻与年龄相关疾病的最有效干预措施之一。尽管其全身性作用已得到充分证实，但CR对皮肤生理功能的影响仍知之甚少，且该干预措施能否缓解炎症性皮肤病的进展仍不确定。在此，我们研究了CR对小鼠皮肤屏障功能和炎症反应的影响。我们的结果显示，CR导致皮肤皮下层显著萎缩。屏障蛋白的表达和经表皮水分流失基本保持不变。有趣的是，在稳定状态下，CR小鼠的皮肤炎症细胞因子表达降低。在咪喹莫特（IMQ）诱导的银屑病小鼠模型中，CR治疗减轻了银屑病表型的发病机制，同时银屑病皮肤中mTOR信号的激活减少。综上所述，我们的研究结果揭示了代谢干预与皮肤健康之间的复杂相互作用，表明CR有潜力作为皮肤炎症反应的调节剂。
