Gholizadeh Atefeh, Amjad-Iranagh Sepideh, Halladj Rouein
Department of Chemical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran 15875-4313, Iran.
Department of Materials and Metallurgical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran 15875-4313, Iran.
ACS Omega. 2024 Sep 16;9(39):40433-40445. doi: 10.1021/acsomega.4c02551. eCollection 2024 Oct 1.
Integrating drugs into cellular membranes efficiently is a significant challenge in drug delivery systems. This study aimed to overcome these barriers by utilizing mixed micelles to enhance drug incorporation into cell membranes. We employed coarse-grained molecular dynamics (MD) simulations to investigate the stability and efficacy of micelles composed of dodecylphosphocholine (DPC), a zwitterionic surfactant, and dodecylmaltoside (DDM), a nonionic surfactant, at various mixing ratios. Additionally, we examined the incorporation of a mutated form of Indolicidin (IND) (CP10A), an anti-HIV peptide, into these micelles. This study provides valuable insights for the development of more effective drug delivery systems by optimizing the mixing ratios of DPC and DDM. By balancing stability and penetration efficiency, these mixed micelles can improve the delivery of drugs that face challenges crossing lipid membranes. Such advancements can enhance the efficacy of treatments for various conditions, including viral infections and cancer, by ensuring that therapeutic agents reach their intended cellular targets more effectively.
在药物递送系统中，将药物高效整合到细胞膜中是一项重大挑战。本研究旨在通过利用混合胶束来增强药物掺入细胞膜，从而克服这些障碍。我们采用粗粒度分子动力学（MD）模拟，研究了由两性离子表面活性剂十二烷基磷酸胆碱（DPC）和非离子表面活性剂十二烷基麦芽糖苷（DDM）以不同混合比例组成的胶束的稳定性和功效。此外，我们还研究了抗HIV肽吲哚杀菌素（IND）的突变形式（CP10A）掺入这些胶束的情况。本研究通过优化DPC和DDM的混合比例，为开发更有效的药物递送系统提供了有价值的见解。通过平衡稳定性和渗透效率，这些混合胶束可以改善面临跨越脂质膜挑战的药物的递送。通过确保治疗剂更有效地到达其预期的细胞靶点，此类进展可以提高包括病毒感染和癌症在内的各种病症的治疗效果。
