Dabiri Ali E, Narain Ravin, Peng Yi-Yang, Wang Wenda, Itkins Max, Kassab Ghassan S
3DTholdings, San Diego, CA, USA.
Department of Chemical and Materials Engineering, University of Alberta, Edmonton, AB, Canada.
Sci Technol Adv Mater. 2024 Sep 25;25(1):2409059. doi: 10.1080/14686996.2024.2409059. eCollection 2024.
A sealant has been developed that improves upon current catheter-based treatments in the following ways: 1) Efficient delivery system, 2) No in situ polymerization, 3) No harmful byproducts, and 4) Cost-effective formulation. During the development process, particular attention was given to materials that were tunable, safe, and effective sealant agents. The thermo-responsive properties of poly(N-isopropylacrylamide) (PNIPAM) provides an ideal foundation to develop an optimized solution. Through a combination of model-based and material testing, a hydrogel was developed that balances conformational factors to achieve a customized transition temperature, radiopacity suitable for visualization, mechanical properties suitable for delivery via 3Fr catheter, sufficient cohesion once applied to resist migration under physiological pressures and an improved safety profile. Two applications, embolization of lymphatic leakage and exclusions of the left atrial appendage (LAA), to eliminate LAA dead space to reduce the risk of thromboembolic events, were considered. The material and benchtop results for this product demonstrate the suitability of this new material not only for these applications but also for other potential healthcare applications.
已开发出一种密封剂，它在以下方面改进了当前基于导管的治疗方法：1）高效输送系统；2）无需原位聚合；3）无有害副产物；4）具有成本效益的配方。在开发过程中，特别关注了可调节、安全且有效的密封剂材料。聚（N-异丙基丙烯酰胺）（PNIPAM）的热响应特性为开发优化溶液提供了理想基础。通过基于模型的测试和材料测试相结合，开发出了一种水凝胶，该水凝胶平衡了构象因素，以实现定制的转变温度、适合可视化的射线不透性、适合通过3Fr导管输送的机械性能、应用后具有足够的内聚力以抵抗生理压力下的迁移以及改善的安全性。考虑了两种应用，即栓塞淋巴漏和封堵左心耳（LAA）以消除LAA死腔，从而降低血栓栓塞事件的风险。该产品的材料和台面测试结果表明，这种新材料不仅适用于这些应用，还适用于其他潜在的医疗保健应用。
