Rani Deepa, Varshney Anupam, Rastogi Kanika
Sarojini Naidu Medical College, Department of Pathology, Agra, Uttar Pradesh, India.
Muzaffarnagar Medical College, Department of Pathology, Uttar Pradesh, India.
Autops Case Rep. 2024 Sep 27;14:e2024519. doi: 10.4322/acr.2024.519. eCollection 2024.
Castleman disease (CD) is a rare, benign lymphoproliferative disorder, mostly involving the mediastinal lymph nodes, but can occur wherever lymphoid tissue is found. With only a few published case reports, there needs to be more literature on its cytological findings. We report the case of a 63-year-old female presenting with left upper cervical swelling. Fine needle aspiration cytology smears showed variably sized lymphoid follicles with diminished germinal centers, prominence of follicular dendritic cells, and capillaries traversing some of the follicles. The possibility of a hyaline-vascular type of Castleman disease was suggested. Histopathology confirmed the cytological diagnosis. The index case is being presented to discuss the cytological features of the CD along with its histological and immunohistochemical correlation.
Castleman病（CD）是一种罕见的良性淋巴增生性疾病，主要累及纵隔淋巴结，但在任何有淋巴组织的部位均可发生。由于仅有少数已发表的病例报告，因此需要更多关于其细胞学表现的文献。我们报告一例63岁女性，表现为左上颈部肿胀。细针穿刺细胞学涂片显示大小不一的淋巴滤泡，生发中心减少，滤泡树突状细胞突出，一些滤泡中有毛细血管穿过。提示为透明血管型Castleman病。组织病理学证实了细胞学诊断。现展示该病例以讨论Castleman病的细胞学特征及其组织学和免疫组化相关性。
