Phulware Ravi Hari, Ramteke Prashant, Yadav Rajni, Iyer Venkateswaran K, Mallick Saumyaranjan
Department of Pathology, All India Institute of Medical Science Rishikesh, India.
Department of Pathology, All India Institute of Medical Sciences New Delhi-110029, India.
Am J Blood Res. 2022 Dec 15;12(6):196-200. eCollection 2022.
Castleman disease (CD) is a rare benign disorder presents as a lymph nodal mass in mediastinum, cervical, axillary or abdomen. Due to the presence of dysplastic dendritic cell in a background mature lymphocyte and plasma cell, it mimics Hodgkin disease (HD). Synchronous and metachronous occurrence in HD and CD can also occur. An 11-year-old male presented with cervical lymphadenopathy (3.5 × 3.5 cm). Fine needle aspiration shows atypical binucleate cell in a background of small lymphocytes, a diagnosis of Hodgkin disease is suggested. Excisional biopsy showed classical features of Hyaline vascular Castleman disease. Careful cytological evaluation and clinical correlation is required for definitive diagnosis.
Castleman病（CD）是一种罕见的良性疾病，表现为纵隔、颈部、腋窝或腹部的淋巴结肿块。由于在成熟淋巴细胞和浆细胞背景中存在发育异常的树突状细胞，它酷似霍奇金病（HD）。HD和CD也可同时或异时发生。一名11岁男性出现颈部淋巴结肿大（3.5×3.5厘米）。细针穿刺显示在小淋巴细胞背景中有非典型双核细胞，提示诊断为霍奇金病。切除活检显示为透明血管型Castleman病的典型特征。明确诊断需要仔细的细胞学评估和临床关联。
