Horugsa Nutthakorn, Kim Jiyeon, Kim Samuel, Lalmuanpuii Judy
Department of Pharmacology, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, USA.
Eur J Case Rep Intern Med. 2024 Sep 24;11(10):004853. doi: 10.12890/2024_004853. eCollection 2024.
The Macklin effect plays an essential role in the pathogenesis of spontaneous pneumomediastinum. It is the process by which is there is a blunt alveolar rupture that leads to air dissection through the bronchopulmonary sheaths and spreads into the mediastinum. Theoretically, marijuana use can cause spontaneous pneumomediastinum indirectly by inducing rigorous vomiting. We report a case of a healthy 22-year-old male with a history of recent marijuana use who presented with pneumomediastinum and rhabdomyolysis concurrently. After a thorough investigation, we concluded that this patient had spontaneous pneumomediastinum due to the Macklin effect from severe vomiting.
Spontaneous pneumomediastinum is the presence of air in the mediastinum that occurs from an unclear aetiology.Marijuana use can trigger severe vomiting in patients, leading to spontaneous pneumomediastinum through the Macklin effect.
麦金效应在自发性纵隔气肿的发病机制中起重要作用。它是一个钝性肺泡破裂导致空气沿支气管肺鞘扩散并蔓延至纵隔的过程。理论上，吸食大麻可通过引发剧烈呕吐间接导致自发性纵隔气肿。我们报告一例健康的22岁男性，近期有吸食大麻史，同时出现纵隔气肿和横纹肌溶解。经过全面检查，我们得出结论，该患者因剧烈呕吐引发麦金效应而患有自发性纵隔气肿。
自发性纵隔气肿是指纵隔内出现空气，病因不明。吸食大麻可引发患者剧烈呕吐，通过麦金效应导致自发性纵隔气肿。
