Wang Xueyan, Zhang Jiesong, Chen Chen, Lu Zhonghai, Zhang Dongfeng, Li Suyun
Department of Epidemiology and Health Statistics, School of Public Health, Qingdao University, Qingdao, Shandong, China.
Front Aging Neurosci. 2023 Jun 20;15:1168892. doi: 10.3389/fnagi.2023.1168892. eCollection 2023.
Physical activity plays an important role in cognitive function in older adults, and the threshold effect and saturation effect between physical activity and cognitive function are unclear.
The purpose of this study was to explore the threshold effect and saturation effect between physical activity and cognitive function in the elderly.
The International Physical Activity Questionnaire (IPAQ) was used to measure moderate-intensity physical activity and vigorous-intensity physical activity and total physical activity in older adults. Cognitive function assessment uses the Beijing version of the Montreal Cognitive Assessment Scale (MoCA). The scale consists of seven parts: visual space, naming, attention, language, abstract ability, delayed recall and orientation, for a total of 30 points. The total score of the study participants < 26 was defined as the optimum cutoff point for a definition of mild cognitive impairment (MCI). The multivariable linear regression model was used to initially explore the relationship between physical activity and total cognitive function scores. The logistic regression model was used to assess the relationship between physical activity and cognitive function dimensions and MCI. The threshold effect and saturation effect between the total physical activity and the total cognitive function scores were investigated by smoothed curve fitting.
This cross-sectional survey had a total of 647 participants aged 60 years and older (mean age: 73 years, female: 53.7%). Participants' higher level of physical activity were associated with higher visual space, attention, language, abstract ability, and delayed recall scores ( < 0.05). Physical activity was not statistically associated with naming and orientation. Physical activity was a protective factor for MCI ( < 0.05). Physical activity was positively correlated with total cognitive function scores. There was a saturation effect between total physical activity and total cognitive function scores, and the saturation point was 6546 MET × min/wk.
This study showed a saturation effect between physical activity and cognitive function, and determined an optimal level of physical activity to protect cognitive function. This finding will help update physical activity guidelines based on cognitive function in the elderly.
身体活动在老年人认知功能中起着重要作用，而身体活动与认知功能之间的阈值效应和饱和效应尚不清楚。
本研究旨在探讨老年人身体活动与认知功能之间的阈值效应和饱和效应。
采用国际身体活动问卷（IPAQ）测量老年人的中等强度身体活动、高强度身体活动及总身体活动量。认知功能评估采用北京版蒙特利尔认知评估量表（MoCA）。该量表由视觉空间、命名、注意力、语言、抽象能力、延迟回忆和定向七个部分组成，共30分。将研究参与者总分<26分定义为轻度认知障碍（MCI）的最佳截断点。采用多变量线性回归模型初步探讨身体活动与总认知功能得分之间的关系。采用逻辑回归模型评估身体活动与认知功能维度及MCI之间的关系。通过平滑曲线拟合研究总身体活动量与总认知功能得分之间的阈值效应和饱和效应。
本次横断面调查共有647名60岁及以上参与者（平均年龄：73岁，女性：53.7%）。参与者身体活动水平越高，视觉空间、注意力、语言、抽象能力和延迟回忆得分越高（P<0.05）。身体活动与命名和定向无统计学关联。身体活动是MCI的保护因素（P<0.05）。身体活动与总认知功能得分呈正相关。总身体活动量与总认知功能得分之间存在饱和效应，饱和点为6546代谢当量×分钟/周。
本研究显示了身体活动与认知功能之间的饱和效应，并确定了保护认知功能的最佳身体活动水平。这一发现将有助于根据老年人的认知功能更新身体活动指南。
