Department of Hepato-Gastroenterology C, Ibn Sina Hospital, Mohamed V University, Rabat, Morocco.
Pan Afr Med J. 2024 Sep 2;49:2. doi: 10.11604/pamj.2024.49.2.44247. eCollection 2024.
COVID-19, caused by SARS-CoV-2, has been declared an international public health emergency. Patients with COVID-19, even without a history of liver disease, frequently present with liver test disturbances. Due to the multisystemic involvement of COVID-19, the pathogenesis of liver injury is likely to be multifactorial, involving systemic inflammation, small vessel thrombosis, hepatic hypoxia, and potential drug toxicity, ruling out direct infection of hepatocytes by SARS-CoV-2. COVID-19 can cause severe acute hepatitis. We report the case of a 25-year-old man admitted to emergency with abdominal pain who presented with acute severe liver failure before respiratory signs.
新型冠状病毒病（COVID-19）由严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）引起，已被宣布为国际关注的突发公共卫生事件。即使没有肝脏疾病史，COVID-19 患者也常出现肝功能检查异常。由于 COVID-19 多系统受累，肝损伤的发病机制可能是多因素的，包括全身炎症、小血管血栓形成、肝缺氧和潜在的药物毒性，可排除 SARS-CoV-2 对肝细胞的直接感染。COVID-19 可引起严重急性肝炎。我们报告了一例 25 岁男性患者，因腹痛就诊于急诊，在出现呼吸症状之前就已发生急性肝功能衰竭。
