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阻塞性睡眠呼吸暂停低通气综合征患者肠道微生物群特征与细胞因子水平的相关性分析

Correlation Analysis of Characteristics of Intestinal Microbiota and Cytokine Levels in Patients with Obstructive Sleep Apnea-Hypopnea Syndrome.

作者信息

Liu Kai-Li, Xu Shen-Jie, Chen Si-Wen, Zhang Min-Jie, Ye Ni, Li Jie

机构信息

Department of General Medicine, The First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China.

出版信息

Nat Sci Sleep. 2024 Sep 30;16:1533-1544. doi: 10.2147/NSS.S471264. eCollection 2024.

DOI:10.2147/NSS.S471264
PMID:39372894
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11451461/
Abstract

OBJECTIVE

The aim of this study was to analyze the relationship between the characteristics of the intestinal microbiota and cytokine levels in individuals with different degrees of obstructive sleep apnea-hypopnea syndrome (OSAHS) as well as to investigate intestinal microbiota imbalances in patients with OSAHS and the associated mechanisms.

METHODS

Based on their sleep apnea hypopnea index (AHI), a total of 37 adults were assigned to a control group, a mild OSAHS group, or a moderate-to-severe OSAHS group. Fecal samples were collected to characterize the intestinal microbiota using metagenomic next-generation sequencing (mNGS), while blood samples were collected to detect levels of interleukin-17a (IL-17a), interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) in each group.

RESULTS

  1. There was no significant difference in the Shannon index among the three groups ( > 0.05). The three groups showed significant difference in the relative abundance of and (with values of 3.955 and 7.24, respectively, < 0.05), while showed no significant difference in the relative abundance of , and ( > 0.05). 2. The three groups showed significant difference in the expression of serum IL-17A and TNF-α levels (with values of 18.119 and 10.691, respectively, < 0.05), while showed no significant difference in the expression of IL-10, IL-6, and CRP levels ( > 0.05). 3. Multiple linear regression analysis revealed that the relative abundance of was correlated with changes in BMI and AHI (with values of 2.585 and -0.157, respectively, < 0.05), while the relative abundance of was correlated with changes in IL-17a (with value of -0.161, < 0.05).

CONCLUSION

The study revealed a significant correlation between intestinal microbiota abundance and cytokine levels, suggesting that gut microbiota disruption in OSAHS patients may be linked to systemic chronic inflammation.

摘要

目的

本研究旨在分析不同程度阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者肠道微生物群特征与细胞因子水平之间的关系，并探讨OSAHS患者肠道微生物群失衡情况及其相关机制。

方法

根据睡眠呼吸暂停低通气指数（AHI），将37名成年人分为对照组、轻度OSAHS组或中重度OSAHS组。采集粪便样本，采用宏基因组下一代测序（mNGS）对肠道微生物群进行特征分析，同时采集血液样本，检测每组中白细胞介素-17a（IL-17a）、白细胞介素-10（IL-10）、肿瘤坏死因子-α（TNF-α）和白细胞介素-6（IL-6）的水平。

结果

  1. 三组之间的香农指数无显著差异（>0.05）。三组在[具体微生物名称1]和[具体微生物名称2]的相对丰度上存在显著差异（P值分别为3.955和7.24，P<0.05），而在[具体微生物名称3]、[具体微生物名称4]和[具体微生物名称5]的相对丰度上无显著差异（P>0.05）。2. 三组在血清IL-17A和TNF-α水平的表达上存在显著差异（P值分别为18.119和10.691，P<0.05），而在IL-10、IL-6和CRP水平的表达上无显著差异（P>0.05）。3. 多元线性回归分析显示，[具体微生物名称1]的相对丰度与BMI和AHI的变化相关（P值分别为2.585和-0.157，P<0.05），而[具体微生物名称2]的相对丰度与IL-17a的变化相关（P值为-0.161，P<0.05）。

结论

该研究揭示了肠道微生物群丰度与细胞因子水平之间存在显著相关性，表明OSAHS患者肠道微生物群的破坏可能与全身慢性炎症有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ea6/11451461/0c95d7be6573/NSS-16-1533-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ea6/11451461/0b7eeed48bd2/NSS-16-1533-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ea6/11451461/81a78c9722cb/NSS-16-1533-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ea6/11451461/0c95d7be6573/NSS-16-1533-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ea6/11451461/0b7eeed48bd2/NSS-16-1533-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ea6/11451461/81a78c9722cb/NSS-16-1533-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ea6/11451461/0c95d7be6573/NSS-16-1533-g0003.jpg

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