相似文献
1
Application of PROTACs in Target Identification and Target Validation.
Acta Mater Med. 2024 Feb 21;3(1):72-87. doi: 10.15212/amm-2024-0010. Epub 2024 Mar 21.
2
PROTAC degraders as chemical probes for studying target biology and target validation.
Chem Soc Rev. 2022 Sep 20;51(18):7971-7993. doi: 10.1039/d2cs00478j.
3
PROTAC derivatization of natural products for target identification and drug discovery: Design of evodiamine-based PROTACs as novel REXO4 degraders.
J Adv Res. 2024 Sep;63:219-230. doi: 10.1016/j.jare.2023.10.014. Epub 2023 Oct 31.
4
PROTAC-DB: an online database of PROTACs.
Nucleic Acids Res. 2021 Jan 8;49(D1):D1381-D1387. doi: 10.1093/nar/gkaa807.
5
Degradation of proteins by PROTACs and other strategies.
Acta Pharm Sin B. 2020 Feb;10(2):207-238. doi: 10.1016/j.apsb.2019.08.001. Epub 2019 Aug 13.
6
PROTAC technology: From drug development to probe technology for target deconvolution.
Eur J Med Chem. 2024 Oct 5;276:116725. doi: 10.1016/j.ejmech.2024.116725. Epub 2024 Jul 30.
7
PROTACs: A novel strategy for cancer drug discovery and development.
MedComm (2020). 2023 May 29;4(3):e290. doi: 10.1002/mco2.290. eCollection 2023 Jun.
8
Revolutionizing Drug Targeting Strategies: Integrating Artificial Intelligence and Structure-Based Methods in PROTAC Development.
Pharmaceuticals (Basel). 2023 Nov 24;16(12):1649. doi: 10.3390/ph16121649.
9
An overview of PROTACs: a promising drug discovery paradigm.
Mol Biomed. 2022 Dec 20;3(1):46. doi: 10.1186/s43556-022-00112-0.
10
Development of Liposome Systems for Enhancing the PK Properties of Bivalent PROTACs.
Pharmaceutics. 2023 Aug 8;15(8):2098. doi: 10.3390/pharmaceutics15082098.
引用本文的文献
1
Mechanistic insights into PROTAC-mediated degradation through an integrated framework of molecular dynamics, free energy landscapes, and quantum mechanics: A case study on kinase degraders.
J Comput Aided Mol Des. 2025 Jul 15;39(1):51. doi: 10.1007/s10822-025-00630-3.
2
Unveiling p65 as the target of diphyllin in ameliorating metabolic dysfunction-associated steatotic liver disease via targeted protein degradation technology.
Front Pharmacol. 2025 Apr 28;16:1567639. doi: 10.3389/fphar.2025.1567639. eCollection 2025.
3
A new paradigm for drug discovery in the treatment of complex diseases: drug discovery and optimization.
Chin Med. 2025 Mar 24;20(1):40. doi: 10.1186/s13020-025-01075-4.
4
SPRY1 regulates macrophage M1 polarization in skin aging and melanoma prognosis.
Transl Oncol. 2025 Apr;54:102331. doi: 10.1016/j.tranon.2025.102331. Epub 2025 Feb 28.
5
Peptide Aptamer-Paclitaxel Conjugates for Tumor Targeted Therapy.
Pharmaceutics. 2024 Dec 30;17(1):40. doi: 10.3390/pharmaceutics17010040.
本文引用的文献
1
A potent GPX4 degrader to induce ferroptosis in HT1080 cells.
Eur J Med Chem. 2024 Feb 5;265:116110. doi: 10.1016/j.ejmech.2023.116110. Epub 2023 Dec 31.
2
A general strategy to develop fluorogenic polymethine dyes for bioimaging.
Nat Chem. 2024 Jan;16(1):28-35. doi: 10.1038/s41557-023-01367-y. Epub 2023 Nov 27.
3
BioE3 identifies specific substrates of ubiquitin E3 ligases.
Nat Commun. 2023 Nov 23;14(1):7656. doi: 10.1038/s41467-023-43326-8.
4
Elucidation of E3 ubiquitin ligase specificity through proteome-wide internal degron mapping.
Mol Cell. 2023 Nov 16;83(22):4191-4192. doi: 10.1016/j.molcel.2023.10.021.
5
PROTAC derivatization of natural products for target identification and drug discovery: Design of evodiamine-based PROTACs as novel REXO4 degraders.
J Adv Res. 2024 Sep;63:219-230. doi: 10.1016/j.jare.2023.10.014. Epub 2023 Oct 31.
6
Rational Design of Bioorthogonally Activatable PROTAC for Tumor-Targeted Protein Degradation.
J Med Chem. 2023 Nov 9;66(21):14843-14852. doi: 10.1021/acs.jmedchem.3c01423. Epub 2023 Oct 23.
7
Defining E3 ligase-substrate relationships through multiplex CRISPR screening.
Nat Cell Biol. 2023 Oct;25(10):1535-1545. doi: 10.1038/s41556-023-01229-2. Epub 2023 Sep 21.
8
Facilitated Drug Repurposing with Artemisinin-Derived PROTACs: Unveiling PCLAF as a Therapeutic Target.
J Med Chem. 2023 Aug 24;66(16):11335-11350. doi: 10.1021/acs.jmedchem.3c00824. Epub 2023 Aug 8.
9
Nano Proteolysis Targeting Chimeras (PROTACs) with Anti-Hook Effect for Tumor Therapy.
Angew Chem Int Ed Engl. 2023 Sep 11;62(37):e202308049. doi: 10.1002/anie.202308049. Epub 2023 Aug 4.
10
Self-Assembled Nano-PROTAC Enables Near-Infrared Photodynamic Proteolysis for Cancer Therapy.
J Am Chem Soc. 2023 Aug 2;145(30):16642-16649. doi: 10.1021/jacs.3c04109. Epub 2023 Jul 21.
Zotero 插件