PROTACs在靶点识别和靶点验证中的应用。
Application of PROTACs in Target Identification and Target Validation.
作者信息
Liu Yang, Liang Jing, Zhu Rui, Yang Yueying, Wang Yali, Wei Wenyi, Li Hua, Chen Lixia
机构信息
Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Fujian Key Laboratory of Chinese Materia Medica, Institute of Structural Pharmacology & TCM Chemical Biology, College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
出版信息
Acta Mater Med. 2024 Feb 21;3(1):72-87. doi: 10.15212/amm-2024-0010. Epub 2024 Mar 21.
PROTAC, as a novel therapeutic drug model, has received widespread attention from the academic and pharmaceutical industries. At the same time, PROTAC technology has led many researchers to focus on developing chemical biology tool properties due to its unique operating mechanism and protein dynamic regulatory properties. In recent years, the rapid development of PROTAC technology has gradually made it an essential tool for target identification and target validation. To further promote the application of PROTAC tools in drug discovery and basic medical sciences research, this review distinguished between target identification and target validation concepts. It summarized the research progress of PROTAC technology in these aspects.
PROTAC作为一种新型治疗药物模型，已受到学术界和制药行业的广泛关注。同时，PROTAC技术因其独特的作用机制和蛋白质动态调控特性，引领众多研究人员专注于开发化学生物学工具特性。近年来，PROTAC技术的快速发展逐渐使其成为靶点识别和靶点验证的重要工具。为进一步推动PROTAC工具在药物发现和基础医学研究中的应用，本综述区分了靶点识别和靶点验证的概念。总结了PROTAC技术在这些方面的研究进展。
Zotero 插件