Shen Xinyang, Ma Yuan, Luo Hang, Abdullah Razack, Pan Yufei, Zhang Yihao, Zhong Chuanxin, Zhang Baoting, Zhang Ge
Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR 999077, China.
Pharmaceutics. 2024 Dec 30;17(1):40. doi: 10.3390/pharmaceutics17010040.
: Traditional paclitaxel therapy often results in significant side effects due to its non-specific targeting of cancer cells. Peptide aptamer-paclitaxel conjugates present a promising alternative by covalently attaching paclitaxel to a versatile peptide aptamer via a linker. Compared to antibody-paclitaxel conjugates, peptide aptamer-paclitaxel conjugates offer several advantages, including a smaller size, lower immunogenicity, improved tissue penetration, and easier engineering. : This review provides an in-depth analysis of the multifunctional peptide aptamers in these conjugates, emphasizing their structural features, therapeutic efficacy, and challenges in clinical applications. : This analysis highlights the potential of peptide aptamer-paclitaxel conjugates as a novel and effective approach for targeted cancer therapy. By harnessing the unique properties of peptide aptamers, these conjugates demonstrate significant promise in improving drug delivery efficiency while reducing the adverse effects associated with traditional paclitaxel therapy. : The incorporation of peptide aptamers into paclitaxel conjugates offers a promising pathway for developing more efficient and targeted cancer therapies. However, further research and clinical studies are essential to fully unlock the therapeutic potential of these innovative conjugates and enhance patient outcomes.
传统的紫杉醇疗法由于其对癌细胞的非特异性靶向作用，常常会导致显著的副作用。肽适配体 - 紫杉醇缀合物通过连接子将紫杉醇共价连接到多功能肽适配体上，提供了一种有前景的替代方案。与抗体 - 紫杉醇缀合物相比，肽适配体 - 紫杉醇缀合物具有几个优点，包括尺寸更小、免疫原性更低、组织穿透性更好以及工程化更容易。：本综述对这些缀合物中的多功能肽适配体进行了深入分析，强调了它们的结构特征、治疗效果以及临床应用中的挑战。：该分析突出了肽适配体 - 紫杉醇缀合物作为一种新型有效靶向癌症治疗方法的潜力。通过利用肽适配体的独特性质，这些缀合物在提高药物递送效率同时减少与传统紫杉醇疗法相关的不良反应方面显示出巨大前景。：将肽适配体纳入紫杉醇缀合物为开发更高效、靶向性更强的癌症治疗方法提供了一条有前景的途径。然而，进一步的研究和临床研究对于充分释放这些创新缀合物的治疗潜力并改善患者预后至关重要。
