Ozkalayci Ozgur, Tastekin Nihal
Bolu İzzet Baysal Mental Health and Diseases Hospital, Bolu, Turkey.
Int J Psychiatry Clin Pract. 2024 Jun;28(2):107-113. doi: 10.1080/13651501.2024.2412641. Epub 2024 Oct 7.
In this study, we wanted to investigate the usability of routine blood samples taken at the beginning of hospitalisation in inpatients to predict the presence of psychotic symptoms in patients.
We divided the hospitalised patients into two groups those with and without psychotic symptoms according to their ICD-10 diagnosis codes. Then, we compared the complete blood count, c-reactive protein (CRP), and fasting glucose levels, which can be used as simple markers of inflammation.
In this retrospective study, which included 349 patients, we found that blood leukocytes, neutrophils, CRP, and fasting glucose levels were higher in patients with psychotic symptoms than in patients without psychotic symptoms ( = 0.015; = 0.013; = 0.002; and = 0.001, respectively). According to regression analysis, patients with high glucose levels were 4.9 times more likely to have psychotic symptoms than those with low glucose levels. In addition, according to the ROC analysis results; when we used 87 mg/dl as the cut-off value for fasting glucose, it was observed that it predicted psychotic symptoms with approximately 69% sensitivity and 71% specificity.
Although our results still have some limitations, they are promising for the future use of simple biomarkers of inflammation for the differential diagnosis of psychiatric disorders.
在本研究中，我们想要调查住院患者入院之初采集的常规血样用于预测患者精神症状存在情况的可用性。
我们根据ICD - 10诊断编码将住院患者分为两组，即有精神症状组和无精神症状组。然后，我们比较了全血细胞计数、C反应蛋白（CRP）和空腹血糖水平，这些可作为炎症的简单标志物。
在这项纳入349例患者的回顾性研究中，我们发现有精神症状患者的血白细胞、中性粒细胞、CRP和空腹血糖水平高于无精神症状患者（分别为= 0.015；= 0.013；= 0.002；以及= 0.001）。根据回归分析，高血糖水平患者出现精神症状的可能性是低血糖水平患者的4.9倍。此外，根据ROC分析结果；当我们将87mg/dl作为空腹血糖的临界值时，观察到它预测精神症状的敏感性约为69%，特异性约为71%。
尽管我们的结果仍有一些局限性，但它们为未来使用简单的炎症生物标志物进行精神障碍的鉴别诊断带来了希望。
